HMMR 抗体 (AA 1-250)
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Quick Overview for HMMR 抗体 (AA 1-250) (ABIN7868943)
抗原
See all HMMR 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 1-250
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原理
- CD168 Antibody / HMMR (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant partial protein sequence (within amino acids 1-250) from the human protein was used as the immunogen for the CD168 antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the CD168 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the CD168 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))
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别名
- CD168
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背景
- Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan that regulates cell adhesion and migration. HA effects are mediated through two receptors, CD44 (also designated HCAM) and the receptor of hyaluronic acid mediated motility (RHAMM). RHAMM, also designated intracellular hyaluronic acid binding protein (IHABP) and CD168, is a matrix receptor, which is linked to the plasma membrane by a GPI anchor and regulates cell motility. RHAMM expression is upregulated in malignant lymphoid tissues and is subsequently implicated in tumor progression and metastasis formation, as well as signal transduction. Although still unclear, RHAMM is thought to exist as several isoforms ranging in size. A variant isoform, designated v4, is a protein that when over-expressed, is thought to be the cause of transformation and metastasis formation in fibroblasts.
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UniProt
- O75330
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途径
- Glycosaminoglycan Metabolic Process
抗原
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