PDX1 抗体 (pan)
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Quick Overview for PDX1 抗体 (pan) (ABIN7868924)
抗原
See all PDX1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-246, pan
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原理
- Zebrafish Pdx1 Antibody / Pancreas/duodenum homeobox protein 1
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Pdx1 recombinant protein (amino acids M1-S246) was used as the immunogen for the Zebrafish Pdx1 antibody.
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亚型
- Ig Fraction
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anti-Pancreatic and Duodenal Homeobox 1 (PDX1) (AA 1-284) antibody
PDX1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Pancreatic and Duodenal Homeobox 1 (PDX1) antibodyPDX1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 2G12 unconjugated
anti-Pancreatic and Duodenal Homeobox 1 (PDX1) antibodyKD Validated PDX1 适用: 人 WB, ICC, FACS, IF (p) 宿主: 兔 Monoclonal 24GB1380 unconjugated Recombinant Antibody
anti-Pancreatic and Duodenal Homeobox 1 (PDX1) (AA 1-30) antibodyPDX1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Pancreatic and Duodenal Homeobox 1 (PDX1) (AA 1-30) antibodyPDX1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB15204 unconjugated
anti-Pancreatic and Duodenal Homeobox 1 (PDX1) antibodyPDX1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pancreatic and Duodenal Homeobox 1 (PDX1) (AA 1-283) antibodyPDX1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Pancreatic and Duodenal Homeobox 1 (PDX1) antibodyPDX1 适用: 人 WB, FACS, EIA 宿主: 小鼠 Monoclonal 5A5 unconjugated
anti-Pancreatic and Duodenal Homeobox 1 (PDX1) (AA 188-284) antibodyPDX1 适用: 大鼠, 山羊 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Pancreatic and Duodenal Homeobox 1 (PDX1) (AA 136-169) antibodyPDX1 适用: 小鼠 WB, IF 宿主: 兔 Polyclonal RB51197 unconjugated
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应用备注
- Optimal dilution of the Zebrafish Pdx1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Pdx1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PDX1 (Pancreatic and Duodenal Homeobox 1 (PDX1))
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别名
- Pdx1
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背景
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Pdx1 (Pancreatic and duodenal homeobox 1) is a transcription factor that plays a critical role in pancreatic development and insulin production. It is essential for the development of the pancreas and the maintenance of beta-cell function in adults. Pdx1 regulates the expression of genes involved in pancreatic morphogenesis, beta-cell differentiation, and glucose metabolism.
In zebrafish, Pdx1 is an ortholog of the human PDX1 gene. Both zebrafish and human Pdx1 proteins share significant sequence similarity and functional conservation, particularly in regulating pancreatic development and insulin gene expression. The similarities between the zebrafish and human versions of Pdx1 make zebrafish an excellent model for studying pancreatic biology, beta-cell development, and diabetes.
During embryogenesis, Pdx1 is highly expressed in the developing pancreas, where it directs the differentiation of pancreatic progenitor cells into insulin-producing beta cells. In zebrafish, Pdx1 is essential for the formation of the pancreatic islets and the regulation of insulin secretion in response to blood glucose levels. Pdx1 also plays a key role in beta-cell regeneration after injury, making it a critical factor in pancreatic plasticity.
Zebrafish Pdx1 is expressed predominantly in the pancreas and duodenum during development and in adult stages. The protein regulates the expression of several downstream genes involved in pancreatic endocrine function and beta-cell maturation, including insulin, glucagon, and somatostatin. Pdx1 also interacts with other transcription factors involved in pancreatic development, such as Ngn3 and Pax4, to coordinate the formation of the pancreatic islet.
Given its essential role in pancreatic development, insulin production, and beta-cell regeneration, zebrafish Pdx1 is an important model for studying type 1 and type 2 diabetes, as well as pancreatic diseases and beta-cell dysfunction. The zebrafish model offers a unique opportunity to study pancreatic regeneration, gene regulation, and metabolic disorders in real time.
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UniProt
- Q6DC85
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途径
- Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Hormone Transport, Carbohydrate Homeostasis, Chromatin Binding, Maintenance of Protein Location
抗原
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