SGCZ 抗体 (AA 1-245)
The 兔 多克隆 anti-SGCZ antibody (ABIN7868917) specifically detects SGCZ in WB, ELISA 和 FACS.
The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN7868917
发货至:
中国
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Contact Info
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中国
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Quick Overview for SGCZ 抗体 (AA 1-245) (ABIN7868917)
抗原
See all SGCZ 抗体
SGCZ
(Sarcoglycan, zeta (SGCZ))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This SGCZ antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Flow Cytometry (FACS)
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抗原表位
- AA 1-245
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原理
- SGCZ Antibody / Sarcoglycan zeta
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SGCZ recombinant protein (Position: M1-L245) was used as the immunogen for the SGCZ antibody.
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亚型
- IgG
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anti-Sarcoglycan, zeta (SGCZ) (C-Term) antibody
SGCZ 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SGCZ antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SGCZ antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SGCZ (Sarcoglycan, zeta (SGCZ))
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别名
- SGCZ
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背景
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SGCZ antibody detects Sarcoglycan zeta, a transmembrane glycoprotein that forms part of the sarcoglycan complex within the dystrophin-associated glycoprotein complex (DGC). The UniProt recommended name is Sarcoglycan zeta (SGCZ). This protein contributes to the mechanical stability of muscle cell membranes and signal transduction between the extracellular matrix and cytoskeleton.
Functionally, SGCZ antibody identifies a 243-amino-acid single-pass membrane protein primarily expressed in skeletal and cardiac muscle. SGCZ associates with alpha-, beta-, gamma-, and delta-sarcoglycans to form a heterotetrameric complex that links dystrophin to the sarcolemma. This interaction is critical for maintaining membrane integrity during muscle contraction and relaxation cycles. SGCZ also participates in intracellular signaling that regulates calcium handling and muscle fiber repair.
The SGCZ gene is located on chromosome 8p22 and is expressed in skeletal muscle, heart, and smooth muscle tissues. Its transcription is regulated by myogenic factors including MYOD1 and MEF2, aligning expression with muscle differentiation and regeneration. SGCZ contributes to muscle architecture by connecting the cytoskeleton to the extracellular matrix through dystrophin and laminin interactions.
Pathologically, mutations in SGCZ cause limb-girdle muscular dystrophy type 2C-related phenotypes and contribute to sarcoglycanopathy spectrum disorders. Deficiency leads to sarcolemma fragility, fiber necrosis, and progressive muscle weakness. Reduced expression has also been observed in cardiomyopathies, where it contributes to cardiac dysfunction. Research using SGCZ antibody supports studies in muscle disease, sarcolemma structure, and dystrophin complex biology.
SGCZ antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect membrane glycoproteins in muscle tissue. NSJ Bioreagents provides SGCZ antibody reagents optimized for studies in muscular dystrophy, sarcolemmal stability, and myogenesis.
Structurally, Sarcoglycan zeta contains an extracellular glycosylated domain and a short cytoplasmic tail anchoring it to the dystrophin-associated complex. It interacts directly with beta- and delta-sarcoglycans and indirectly stabilizes dystrophin. This antibody facilitates exploration of SGCZ's role in muscle membrane integrity, mechanical signaling, and dystrophic pathology. -
UniProt
- Q96LD1
抗原
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