UPF0568 Protein C14orf166 (RTRAF) (AA 1-244) 抗体
The 兔 多克隆 anti-UPF0568 Protein C14orf166 antibody is suitable to detect UPF0568 Protein C14orf166 in samples from 人, 小鼠 和 大鼠. It has been validated for ELISA, IHC, WB, IF 和 ICC.
产品编号 ABIN7868916
发货至:
中国
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Quick Overview for UPF0568 Protein C14orf166 (RTRAF) (AA 1-244) 抗体 (ABIN7868916)
抗原
UPF0568 Protein C14orf166 (RTRAF)
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
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抗原表位
- AA 1-244
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原理
- RTRAF Antibody / hCLE
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human C14orf166/RTRAF recombinant protein (Position: M1-R244) was used as the immunogen for the RTRAF antibody.
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亚型
- IgG
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anti-UPF0568 Protein C14orf166 (RTRAF) (AA 1-244) antibody
RTRAF 适用: 人 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-UPF0568 Protein C14orf166 (RTRAF) antibodyRTRAF 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB5625 unconjugated
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应用备注
- Optimal dilution of the RTRAF antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the RTRAF antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- UPF0568 Protein C14orf166 (RTRAF)
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别名
- RTRAF
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背景
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RTRAF antibody detects RNA transcription, translation, and transport factor, a multifunctional RNA-binding protein involved in mRNA export, transcriptional regulation, and translation initiation. RTRAF interacts with transcription machinery and translation factors, serving as a molecular bridge that coordinates gene expression at multiple levels. The RTRAF antibody is used in RNA biology, gene expression, and epigenetic studies to investigate transcriptional and post-transcriptional regulation.
RTRAF is encoded by the RTRAF gene located on human chromosome 17q23.3. The protein is approximately 375 amino acids long and localizes to both the nucleus and cytoplasm, reflecting its diverse functions. It forms complexes with RNA polymerase II, transcription elongation factors, and RNA helicases, linking transcription with RNA processing and export. RTRAF also associates with translation initiation factor eIF3, regulating mRNA translation efficiency.
The RTRAF antibody detects a 43 kilodalton band by western blot and demonstrates both nuclear speckle and cytoplasmic punctate staining in immunofluorescence assays. RTRAF participates in gene expression control by influencing promoter clearance, mRNA splicing, and ribosome loading. Its loss disrupts RNA metabolism, leading to reduced protein synthesis and altered stress granule dynamics.
Functionally, RTRAF has been linked to viral replication, as it enhances viral RNA translation and replication complex assembly in infected cells. In cancer, RTRAF expression correlates with increased proliferation and tumor aggressiveness due to its role in sustaining translation of growth-related mRNAs. It also contributes to chromatin organization by interacting with histone modifiers and transcriptional regulators.
Through its integration of transcription, RNA transport, and translation, RTRAF acts as a key coordinator of gene expression homeostasis. NSJ Bioreagents provides a validated RTRAF antibody optimized for its applications, enabling in-depth study of RNA processing, translation control, and gene regulation under physiological and pathological conditions. -
UniProt
- Q9Y224
抗原
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