BCAP31 抗体 (AA 1-242)
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北京 101111
Quick Overview for BCAP31 抗体 (AA 1-242) (ABIN7868908)
抗原
See all BCAP31 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-242
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原理
- BCAP31 Antibody / B-cell receptor-associated protein 31
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human BAP31/BCAP31 recombinant protein (Position: M1-D242) was used as the immunogen for the BCAP31 antibody.
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亚型
- IgG
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anti-B-Cell Receptor-Associated Protein 31 (BCAP31) (AA 2-243) antibody
BCAP31 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-B-Cell Receptor-Associated Protein 31 (BCAP31) (AA 137-246) antibodyBCAP31 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C5 unconjugated
anti-B-Cell Receptor-Associated Protein 31 (BCAP31) (AA 1-246) antibodyBCAP31 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-B-Cell Receptor-Associated Protein 31 (BCAP31) (AA 1-246) antibodyBCAP31 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-B-Cell Receptor-Associated Protein 31 (BCAP31) (C-Term) antibodyBCAP31 适用: 人, 小鼠, 大鼠, 猴, 犬, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-B-Cell Receptor-Associated Protein 31 (BCAP31) (AA 127-246) antibodyBCAP31 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-B-Cell Receptor-Associated Protein 31 (BCAP31) antibodyKD Validated BCAP31 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB3680 unconjugated Recombinant Antibody
anti-B-Cell Receptor-Associated Protein 31 (BCAP31) (AA 120-147) antibodyBCAP31 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-B-Cell Receptor-Associated Protein 31 (BCAP31) (Middle Region) antibodyBCAP31 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-B-Cell Receptor-Associated Protein 31 (BCAP31) antibodyBCAP31 适用: 人 WB, IHC (p) 宿主: 小鼠 Monoclonal 2C6 unconjugated
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应用备注
- Optimal dilution of the BCAP31 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the BCAP31 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- BCAP31 (B-Cell Receptor-Associated Protein 31 (BCAP31))
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别名
- BCAP31
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背景
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BCAP31 antibody detects B-cell receptor-associated protein 31, an integral endoplasmic reticulum (ER) membrane protein that functions as a chaperone and adaptor in protein trafficking and apoptosis regulation. BCAP31 is a member of the BCAP31 family, which includes BCAP29, and plays crucial roles in protein quality control, ER-Golgi transport, and caspase-mediated cell death. The BCAP31 antibody is used in cell biology and immunology research to study membrane trafficking, ER stress, and apoptotic signaling.
BCAP31 is encoded by the BCAP31 gene located on the X chromosome (Xp22.13). The protein is approximately 28 kilodaltons and contains three transmembrane domains with a cytoplasmic C-terminal tail that interacts with diverse partners, including BCL2 and procaspase-8. These interactions position BCAP31 at the intersection of the secretory and apoptotic pathways, integrating ER homeostasis with cell death regulation.
The BCAP31 antibody detects a 28 kilodalton band on western blot and shows reticular ER staining consistent with its localization. BCAP31 forms complexes with chaperones such as calnexin and Sec61, assisting in the folding and export of glycoproteins from the ER to the Golgi apparatus. It also mediates ER retention or degradation of misfolded proteins, linking it to the unfolded protein response (UPR).
In apoptosis, BCAP31 acts as a substrate for caspase cleavage, generating pro-apoptotic fragments that amplify death signaling through mitochondria. This dual role allows BCAP31 to serve as both a quality control checkpoint and a stress sensor. Mutations or deletions of BCAP31 cause X-linked intellectual disability syndromes characterized by developmental delay and hearing loss, emphasizing its importance in neuronal maintenance.
BCAP31 also contributes to immune cell signaling and antigen presentation by modulating trafficking of MHC class I molecules. NSJ Bioreagents provides a validated BCAP31 antibody optimized for western blot, immunofluorescence, and ER-Golgi transport analysis, supporting research into protein folding, apoptosis regulation, and membrane trafficking. -
UniProt
- P51572
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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