PSMA5 抗体 (AA 1-241)
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北京 101111
Quick Overview for PSMA5 抗体 (AA 1-241) (ABIN7868907)
抗原
See all PSMA5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-241
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原理
- PSMA5 Antibody / Proteasome subunit alpha type 5
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纯化方法
- Antigen Affinity purified
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免疫原
- Amino acids M1-I241 from the human protein were used as the immunogen for the PSMA5 antibody.
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亚型
- IgG
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anti-Proteasome Subunit alpha 5 (PSMA5) (AA 1-241) antibody
PSMA5 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) (Center) antibodyPSMA5 适用: 人, 小鼠 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) antibodyPSMA5 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF 宿主: 小鼠 Monoclonal 426CT8-5-1 unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) (AA 124-180) antibodyPSMA5 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) antibodyPSMA5 适用: 人, 大鼠 WB, IHC (p), IF 宿主: 小鼠 Monoclonal 6T1 unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) (AA 132-241) antibodyPSMA5 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) (AA 100-150) antibodyPSMA5 适用: 人, 小鼠 WB, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) antibodyPSMA5 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB7405 unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) antibodyPSMA5 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB7175 unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) antibodyPSMA5 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB1970 unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the PSMA5 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PSMA5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PSMA5 (Proteasome Subunit alpha 5 (PSMA5))
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别名
- PSMA5
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背景
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PSMA5 antibody is a valuable reagent for studying protein degradation and cellular homeostasis. The encoded protein, proteasome subunit alpha type 5, is a core component of the 20S proteasome, a large multi-catalytic complex responsible for degrading ubiquitinated proteins. The proteasome plays a central role in maintaining protein quality control, regulating cell cycle progression, and modulating signaling pathways. PSMA5 belongs to the alpha subunit family, which forms part of the structural gate controlling substrate entry into the catalytic chamber of the proteasome.
PSMA5 contributes to the assembly and stability of the proteasome complex. The alpha subunits, including PSMA5, form a heptameric ring that shapes one end of the barrel-like core. This arrangement functions as a regulated gate, opening to allow access of protein substrates targeted for degradation. By influencing the selectivity and efficiency of protein turnover, PSMA5 is critical for cellular responses to stress, metabolic regulation, and removal of damaged or misfolded proteins.
Research into PSMA5 has highlighted its importance in diverse biological processes. Proteasome activity, dependent on components such as PSMA5, is required for antigen processing, generating peptides that are presented by MHC class I molecules to cytotoxic T lymphocytes. This immune surveillance mechanism is essential for identifying and destroying infected or transformed cells. In addition, proteasome function regulates transcription factors, signaling proteins, and cell cycle regulators, placing PSMA5 at the heart of pathways that determine proliferation, differentiation, and apoptosis.
Alterations in proteasome activity have been associated with cancer, neurodegenerative disorders, and inflammatory disease. Dysregulation of PSMA5 expression or proteasome activity can disrupt protein turnover, contributing to abnormal signaling and accumulation of toxic protein aggregates. Pharmacologic inhibitors of the proteasome, such as bortezomib, underscore the therapeutic relevance of targeting this pathway, with PSMA5 as a structural and functional element within the proteasome complex.
The PSMA5 antibody is widely used in western blotting, immunohistochemistry, immunofluorescence, and flow cytometry to detect expression levels and subcellular localization of this proteasome subunit. Such applications are essential for assessing changes in protein degradation capacity across tissues, during disease progression, or under experimental manipulation. For scientists investigating protein quality control, immune responses, or therapeutic intervention strategies, the PSMA5 antibody provides a reliable and precise detection tool. NSJ Bioreagents offers validated antibodies that ensure consistent and reproducible results for advanced research. -
UniProt
- P28066
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途径
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
抗原
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