PSMA5 抗体 (AA 1-241)
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Quick Overview for PSMA5 抗体 (AA 1-241) (ABIN7868906)
抗原
See all PSMA5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-241
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原理
- Zebrafish Psma5 Antibody / Proteasome subunit alpha type 5
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Psma5 recombinant protein (amino acids M1-I241) was used as the immunogen for the Zebrafish Psma5 antibody.
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亚型
- Ig Fraction
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anti-Proteasome Subunit alpha 5 (PSMA5) (AA 1-241) antibody
PSMA5 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) (Center) antibodyPSMA5 适用: 人, 小鼠 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) antibodyPSMA5 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF 宿主: 小鼠 Monoclonal 426CT8-5-1 unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) (AA 124-180) antibodyPSMA5 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) antibodyPSMA5 适用: 人, 大鼠 WB, IHC (p), IF 宿主: 小鼠 Monoclonal 6T1 unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) (AA 132-241) antibodyPSMA5 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) (AA 100-150) antibodyPSMA5 适用: 人, 小鼠 WB, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) antibodyPSMA5 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB7405 unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) antibodyPSMA5 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB7175 unconjugated
anti-Proteasome Subunit alpha 5 (PSMA5) antibodyPSMA5 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB1970 unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the Zebrafish Psma5 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Psma5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PSMA5 (Proteasome Subunit alpha 5 (PSMA5))
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别名
- Psma5
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背景
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Psma5 (Proteasome subunit alpha type 5) is a structural component of the 20S core particle of the proteasome, a key intracellular complex responsible for the ATP-independent degradation of ubiquitinated proteins. Psma5 belongs to the alpha subunit family, which forms the two outer rings of the proteasome core. These alpha subunits regulate substrate entry into the proteolytic chamber formed by the beta subunits and are essential for proteasome assembly, stability, and function.
In zebrafish, Psma5 is the ortholog of the human PSMA5 gene. The protein sequence and functional domains are highly conserved between zebrafish and humans, indicating a shared role in proteasome-mediated protein degradation. This evolutionary conservation supports the use of zebrafish as a model organism for studying proteostasis, developmental regulation, and disease mechanisms related to proteasome dysfunction.
Zebrafish Psma5 may have multiple isoforms generated through alternative splicing. These isoforms could allow tissue-specific or developmental stage-specific regulation of proteasome activity, although the canonical isoform is primarily involved in the assembly and function of the standard 20S proteasome.
During zebrafish embryogenesis, Psma5 is broadly expressed in rapidly proliferating and metabolically active tissues, including the developing brain, eye, musculature, and digestive organs. Its expression reflects the universal need for controlled protein degradation in processes such as cell cycle progression, signal transduction, and removal of damaged or misfolded proteins.
In human biology, defects in proteasome components including PSMA5 have been associated with neurodegenerative diseases, cancers, and immune system disorders. Zebrafish Psma5, due to its conserved function, serves as a valuable model for functional studies of the proteasome and for the development of therapeutics targeting the ubiquitin-proteasome system.
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UniProt
- Q6TGV6
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途径
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
抗原
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