GTPase, IMAP Family Member 1 (GIMAP1) (AA 1-238) 抗体
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Quick Overview for GTPase, IMAP Family Member 1 (GIMAP1) (AA 1-238) 抗体 (ABIN7868892)
抗原
See all GTPase, IMAP Family Member 1 (GIMAP1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-238
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原理
- GIMAP1 Antibody / GTPase IMAP family member 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human GIMAP1 recombinant protein (Position: M1-E238) was used as the immunogen for the GIMAP1 antibody.
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亚型
- IgG
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anti-GTPase, IMAP Family Member 1 (GIMAP1) (N-Term) antibody
GIMAP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-GTPase, IMAP Family Member 1 (GIMAP1) (N-Term) antibodyGIMAP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-GTPase, IMAP Family Member 1 (GIMAP1) (N-Term) antibodyGIMAP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GIMAP1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GIMAP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GTPase, IMAP Family Member 1 (GIMAP1)
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别名
- GIMAP1
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背景
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GIMAP1 antibody detects GTPase IMAP family member 1, a small GTP-binding protein involved in lymphocyte survival and immune regulation. The UniProt recommended name is GTPase IMAP family member 1 (GIMAP1). This protein belongs to the GIMAP (GTPase of immunity-associated proteins) family, which participates in T-cell development, apoptosis resistance, and mitochondrial homeostasis within immune cells.
Functionally, GIMAP1 antibody identifies a 320-amino-acid cytoplasmic and mitochondrial membrane-associated GTPase. GIMAP1 regulates cell survival by maintaining mitochondrial integrity and preventing apoptotic signaling during lymphocyte maturation. It interacts with other GIMAP family members and BCL2-related proteins to modulate intrinsic apoptosis pathways. GIMAP1 expression is induced during T-cell activation and may help coordinate metabolic adaptation and survival under stress conditions.
The GIMAP1 gene is located on chromosome 7q36.1 and is expressed predominantly in thymus, spleen, and peripheral lymphocytes. Its expression pattern mirrors that of immune cell differentiation markers, underscoring its role in adaptive immunity. GIMAP1 acts as a key survival regulator in the transition of T-cells from double-positive to single-positive stages in the thymus.
Pathologically, GIMAP1 dysregulation has been linked to autoimmune disorders and lymphoid malignancies. Loss of function leads to increased apoptosis of lymphocytes and immunodeficiency, while overexpression contributes to T-cell survival in leukemia. Research using GIMAP1 antibody supports studies in immunology, cell survival pathways, and mitochondrial regulation in immune cells.
GIMAP1 antibody is validated for western blotting, immunofluorescence, and flow cytometry to detect small GTPases involved in immune cell regulation. NSJ Bioreagents provides GIMAP1 antibody reagents optimized for research in lymphocyte biology, apoptosis resistance, and mitochondrial signaling.
Structurally, GTPase IMAP family member 1 contains conserved GTP-binding motifs typical of small GTPases, including the P-loop, switch I, and switch II regions that mediate nucleotide binding and hydrolysis. Its membrane association and GTP-dependent conformational changes regulate interactions with mitochondrial and cytoskeletal components. This antibody enables detailed analysis of GIMAP1's role in immune homeostasis and cell survival signaling. -
UniProt
- Q8WWP7
抗原
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