TGIF2 抗体 (AA 1-237)
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Quick Overview for TGIF2 抗体 (AA 1-237) (ABIN7868891)
抗原
See all TGIF2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-237
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原理
- TGIF2 Antibody / TG-interacting factor 2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human TGIF2 recombinant protein (Position: M1-Q237) was used as the immunogen for the TGIF2 antibody.
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亚型
- IgG
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anti-TGFB-Induced Factor Homeobox 2 (TGIF2) (AA 131-236) antibody
TGIF2 适用: 人 ELISA, WB, RNAi 宿主: 小鼠 Monoclonal 4C10 unconjugated
anti-TGFB-Induced Factor Homeobox 2 (TGIF2) (AA 131-236) antibodyTGIF2 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 6A8 unconjugated
anti-TGFB-Induced Factor Homeobox 2 (TGIF2) (AA 131-236) antibodyTGIF2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 6B10 unconjugated
anti-TGFB-Induced Factor Homeobox 2 (TGIF2) (AA 114-175) antibodyTGIF2 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 4B10 unconjugated
anti-TGFB-Induced Factor Homeobox 2 (TGIF2) (AA 1-237) antibodyTGIF2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2F3 unconjugated
anti-TGFB-Induced Factor Homeobox 2 (TGIF2) (AA 1-237) antibodyTGIF2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-TGFB-Induced Factor Homeobox 2 (TGIF2) (AA 82-222) antibodyTGIF2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TGFB-Induced Factor Homeobox 2 (TGIF2) (AA 1-237) antibodyTGIF2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 3G8 unconjugated
anti-TGFB-Induced Factor Homeobox 2 (TGIF2) (Internal Region) antibodyVerified TGIF2 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-TGFB-Induced Factor Homeobox 2 (TGIF2) (AA 131-236) antibodyTGIF2 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the TGIF2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TGIF2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TGIF2 (TGFB-Induced Factor Homeobox 2 (TGIF2))
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别名
- TGIF2
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背景
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TGIF2 antibody detects TG-interacting factor 2, a homeodomain transcriptional repressor that modulates TGF-beta signaling and developmental gene expression. The UniProt recommended name is TG-interacting factor 2 (TGIF2). This nuclear protein belongs to the TALE (three-amino acid loop extension) class of homeobox proteins and functions as a DNA-binding corepressor that inhibits Smad-mediated transcription.
Functionally, TGIF2 antibody identifies a 237-amino-acid protein localized in the nucleus, where it binds DNA at consensus homeobox sites and interacts with transcriptional repressors such as CtBP and HDACs. TGIF2 represses TGF-beta target genes by blocking Smad binding to promoters, fine-tuning cellular differentiation, proliferation, and morphogenesis during embryonic development.
The TGIF2 gene is located on chromosome 20q11.2 and is expressed in embryonic tissues and adult organs including brain, kidney, and testis. TGIF2 acts as a developmental regulator controlling anterior-posterior patterning and organ formation through transcriptional repression mechanisms.
Pathologically, TGIF2 overexpression has been observed in several cancers, including ovarian and gastric tumors, where it promotes cell proliferation and epithelial-mesenchymal transition. Gene duplications or deletions involving TGIF2 have been associated with holoprosencephaly and craniofacial malformations. Research using TGIF2 antibody supports studies in transcriptional repression, developmental biology, and oncogenesis.
TGIF2 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect homeodomain transcription factors. NSJ Bioreagents provides TGIF2 antibody reagents optimized for developmental and transcriptional research applications.
Structurally, TG-interacting factor 2 contains a homeobox DNA-binding domain and a CtBP-binding motif that mediate its repressor activity. This antibody aids in analyzing TGIF2's role in gene regulation, morphogenesis, and signaling cross-talk. -
UniProt
- Q9GZN2
抗原
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