CDK5 抗体 (AA 1-226)
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Quick Overview for CDK5 抗体 (AA 1-226) (ABIN7868863)
抗原
See all CDK5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-226
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原理
- Zebrafish Cdk5 Antibody
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纯化方法
- Antigen affinity chromatography
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免疫原
- An E.coli-derived zebrafish Cdk5 recombinant protein (amino acids M1-Q226) was used as the immunogen for the Zebrafish Cdk5 antibody.
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亚型
- Ig Fraction
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应用备注
- Optimal dilution of the Zebrafish Cdk5 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Cdk5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- CDK5 (Cyclin-Dependent Kinase 5 (CDK5))
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别名
- Cdk5
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背景
- CDK5, Cyclin-Dependent Kinase 5, is also known as PSSALRE. The p34 (CDC2) protein kinase regulates important transitions in the eukaryotic cell cycle. The PSSALRE expression is in all human tissues and cell lines tested. The the CDK5 gene is mapped to chromosome 7q36. Cyclin-dependent kinase-5 is predominantly expressed in neurons where it phosphorylates both high molecular weight neurofilaments and microtubule-associated protein tau. CDK5 is required for proper development of the mammalian central nervous system. To be activated, CDK5 must associate with its regulatory subunit, p35 (CDK5R1). CDK5 can phosphorylate DARPP32 at threonine-75, converting it into an inhibitor of PKA.
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UniProt
- Q9DE44
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途径
- Cell Division Cycle, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis
抗原
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