FAM60A 抗体 (AA 1-221)
The 兔 多克隆 anti-FAM60A antibody is suitable to detect FAM60A in samples from 人 和 大鼠. It has been validated for ELISA, WB, IF, FACS 和 IHC (p).
产品编号 ABIN7868850
发货至:
中国
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Quick Overview for FAM60A 抗体 (AA 1-221) (ABIN7868850)
抗原
FAM60A
(Family with Sequence Similarity 60, Member A (FAM60A))
适用
人, 大鼠
宿主
兔
克隆类型
多克隆
标记
This FAM60A antibody is un-conjugated
应用范围
ELISA, Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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抗原表位
- AA 1-221
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原理
- FAM60A Antibody / SINHCAF
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纯化方法
- Antigen affinity purified
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免疫原
- E. coli-derived recombinant human protein (amino acids M1-W221) was used as the immunogen for the FAM60A antibody.
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亚型
- IgG
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anti-Family with Sequence Similarity 60, Member A (FAM60A) (AA 1-221) antibody
FAM60A 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Family with Sequence Similarity 60, Member A (FAM60A) (AA 1-221) antibodyFAM60A 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the FAM60A antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the FAM60A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- FAM60A (Family with Sequence Similarity 60, Member A (FAM60A))
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别名
- FAM60A
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背景
- FAM60A, also known as Protein FAM60A, Tera protein homolog and SIN3-HDAC complex-associated factor (SINHCAF), is a subunit of the Sin3 deacetylase complex (Sin3/HDAC) that is important for the repression of genes. The SIN3A-HDAC complex deacetylates histones thereby repressing gene transcription. FAM60A specifically impacts genes encoding components of the TGF-beta signaling pathway and promoters of important proteins like cyclin D1. FAM60A activity peaks during G1 and S phases of the cell cycle and is up regulated in many carcinoma and tumor tissues. Additionally, loss of FAM60A leads to a change in cell morphology, an increase in cell migration, increased histone acetylation at the cyclin D1 promoter and elevated levels of cyclin D1 mRNA and protein. Furthermore, depletion of FAM60A altered the periodic association of HDAC1 with the cyclin D1 promoter, increased cyclin D1 expression at all cell cycle phases, and caused premature S phase entry.
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UniProt
- Q9NP50
抗原
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