RAB5 抗体 (AA 1-216)
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Quick Overview for RAB5 抗体 (AA 1-216) (ABIN7868835)
抗原
See all RAB5 (RAB5A) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-216
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原理
- Zebrafish Rab5a Antibody / Rab5aa / Rab5ab
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Rab5a recombinant protein (amino acids M1-N216) was used as the immunogen for the Zebrafish Rab5a antibody.
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亚型
- Ig Fraction
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anti-RAB5A, Member RAS Oncogene Family (RAB5A) antibody
RAB5A 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-RAB5A, Member RAS Oncogene Family (RAB5A) (C-Term) antibodyRAB5A 适用: 人, 小鼠, 大鼠, Cow, 猴, 犬, 绵羊, 马, 兔, 豚鼠, Pig, Hamster, 小鸡, Avian, Cat, 驴, 山羊 WB, IF, IHC (p), IHC (fro) 宿主: 山羊 Polyclonal unconjugated
anti-RAB5A, Member RAS Oncogene Family (RAB5A) (AA 1-215) antibodyRAB5A 适用: 人 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3H5C11 unconjugated
anti-RAB5A, Member RAS Oncogene Family (RAB5A) (C-Term) antibodyRAB5A 适用: 人, 小鼠, 大鼠, Cow, 猴, 犬, 绵羊, 马, 兔, 豚鼠, Pig, Hamster, 小鸡, Avian, Cat, 驴, 山羊 WB, IF, IHC (p), IHC (fro) 宿主: 山羊 Polyclonal unconjugated
anti-RAB5A, Member RAS Oncogene Family (RAB5A) antibody (Atto 390)RAB5A 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 390
anti-RAB5A, Member RAS Oncogene Family (RAB5A) (AA 1-215) antibodyRAB5A 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-RAB5A, Member RAS Oncogene Family (RAB5A) (AA 182-211) antibodyRAB5A 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-RAB5A, Member RAS Oncogene Family (RAB5A) antibody (Atto 488)RAB5A 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 488
anti-RAB5A, Member RAS Oncogene Family (RAB5A) antibody (Biotin)RAB5A 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal Biotin
anti-RAB5A, Member RAS Oncogene Family (RAB5A) antibody (APC)RAB5A 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal APC
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应用备注
- Optimal dilution of the Zebrafish Rab5a antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Rab5a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- RAB5 (RAB5A) (RAB5A, Member RAS Oncogene Family (RAB5A))
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别名
- Rab5a
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背景
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Zebrafish Rab5a is a small GTP binding protein that belongs to the Rab family, which plays a key role in vesicle trafficking within cells. Rab5a is a critical regulator of early endosome fusion and endocytic transport, influencing receptor recycling, signaling pathways, and the sorting of membrane proteins. In zebrafish, Rab5a is involved in dynamic processes during early development, where endosomal trafficking is essential for proper cell signaling and morphogenesis.
Zebrafish Rab5a is an ortholog of the human RAB5A protein and shows a high degree of sequence and functional conservation with its human counterpart. Similar to human RAB5A, zebrafish Rab5a acts as a molecular switch by cycling between an active GTP bound form and an inactive GDP bound form, controlling the recruitment of effectors necessary for vesicle docking and fusion.
In zebrafish, Rab5a exists in 2 isoforms, Rab5aa and Rab5ab. Both isoforms are expressed during embryogenesis and play overlapping but sometimes distinct roles in endosomal dynamics. Rab5aa is often the primary isoform examined in studies of receptor mediated endocytosis, while Rab5ab may have specialized roles in certain tissues or stages of development. The presence of these 2 isoforms provides a unique model to investigate how variations in Rab5 function can impact cellular trafficking pathways.
Antibodies against zebrafish Rab5a protein are valuable for research focusing on vesicle transport, endocytosis, receptor regulation, and developmental biology. The functional similarity between zebrafish Rab5a and human RAB5A also makes this protein an important model for studying conserved mechanisms of intracellular trafficking across species.
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UniProt
- Q7ZUW5
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途径
- Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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