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SNAP23 抗体 (AA 1-211)

The 兔 多克隆 anti-SNAP23 antibody is suitable to detect SNAP23 in samples from 人. It has been validated for WB, ELISA, IF, IHC (p) 和 FACS.
产品编号 ABIN7868826
发货至: 中国
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Quick Overview for SNAP23 抗体 (AA 1-211) (ABIN7868826)

抗原

See all SNAP23 抗体
SNAP23 (Synaptosomal-Associated Protein, 23kDa (SNAP23))

适用

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宿主

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克隆类型

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多克隆

标记

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This SNAP23 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
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    AA 1-211

    原理

    Synaptosomal-associated protein 23 Antibody / SNAP23

    纯化方法

    Antigen affinity purified

    免疫原

    Recombinant human protein (amino acids M1-S211) was used as the immunogen for the Synaptosomal-associated protein 23 antibody.

    亚型

    IgG
  • 应用备注

    Optimal dilution of the Synaptosomal-associated protein 23 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    储存条件

    4 °C,-20 °C

    储存方法

    After reconstitution, the Synaptosomal-associated protein 23 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
  • 抗原

    SNAP23 (Synaptosomal-Associated Protein, 23kDa (SNAP23))

    别名

    Synaptosomal-associated protein 23

    背景

    SNAP23 (Synaptosomal-Associated Protein, 23-KD), also called SNAP23A, is a protein that in humans is encoded by the SNAP23 gene. The SNAP23 gene has 8 exons, with the initiation codon located in exon 2. The SNAP23 gene is mapped on 15q15.1-q15.2. The SNAP23 cDNA encodes a 211-amino acid polypeptide with a predicted mass of 23 kD. Its amino acid sequence is 59 % identical to that of SNAP25. Northern blot analysis revealed that SNAP23 is ubiquitously expressed. SNAP23 is able to bind to multiple syntaxins as well as to multiple vesicle-associated membrane proteins. After relocation, SNAP23 is required for exocytosis, implying a crucial role in promoting membrane fusion. TIVAMP-containing vesicles were concentrated in the apical domain of epithelial cells. STX3A and SNAP23 were codistributed at the apical plasma membrane, where they formed N-ethyl maleimide-dependent SNARE complexes with TIVAMP and cellubrevin. SNAP23 is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion.

    UniProt

    O00161
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