SNAP23 抗体 (AA 1-211)
Our Local Distributor
北京 101111
Quick Overview for SNAP23 抗体 (AA 1-211) (ABIN7868826)
抗原
See all SNAP23 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 1-211
-
原理
- Synaptosomal-associated protein 23 Antibody / SNAP23
-
纯化方法
- Antigen affinity purified
-
免疫原
- Recombinant human protein (amino acids M1-S211) was used as the immunogen for the Synaptosomal-associated protein 23 antibody.
-
亚型
- IgG
-
-
-
-
应用备注
- Optimal dilution of the Synaptosomal-associated protein 23 antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the Synaptosomal-associated protein 23 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- SNAP23 (Synaptosomal-Associated Protein, 23kDa (SNAP23))
-
别名
- Synaptosomal-associated protein 23
-
背景
- SNAP23 (Synaptosomal-Associated Protein, 23-KD), also called SNAP23A, is a protein that in humans is encoded by the SNAP23 gene. The SNAP23 gene has 8 exons, with the initiation codon located in exon 2. The SNAP23 gene is mapped on 15q15.1-q15.2. The SNAP23 cDNA encodes a 211-amino acid polypeptide with a predicted mass of 23 kD. Its amino acid sequence is 59 % identical to that of SNAP25. Northern blot analysis revealed that SNAP23 is ubiquitously expressed. SNAP23 is able to bind to multiple syntaxins as well as to multiple vesicle-associated membrane proteins. After relocation, SNAP23 is required for exocytosis, implying a crucial role in promoting membrane fusion. TIVAMP-containing vesicles were concentrated in the apical domain of epithelial cells. STX3A and SNAP23 were codistributed at the apical plasma membrane, where they formed N-ethyl maleimide-dependent SNARE complexes with TIVAMP and cellubrevin. SNAP23 is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion.
-
UniProt
- O00161
抗原
-