P57 (AA 1-200) 抗体
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北京 101111
Quick Overview for P57 (AA 1-200) 抗体 (ABIN7868692)
抗原
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 1-200
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原理
- p57 Antibody / p57Kip2 (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant fragment (within amino acids 1-200) of human p57Kip2 protein was used as the immunogen for the p57 antibody.
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亚型
- IgG2b, kappa
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anti-P57 (Ser24) antibody
适用: 人, 小鼠, 大鼠 IHC (p), WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-P57 (acLys278) antibody适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-P57 antibodyCarrier-free 适用: 人, 小鼠 IHC (p) 宿主: 小鼠 Monoclonal KP10 unconjugated
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应用备注
- Optimal dilution of the p57 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the p57 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- P57
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背景
- Recognizes a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.
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UniProt
- P49918
抗原
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