TTC36 抗体 (AA 1-187)
The 兔 多克隆 anti-TTC36 antibody is suitable to detect TTC36 in samples from 人 和 小鼠. It has been validated for ELISA, FACS, ICC, IF 和 WB.
产品编号 ABIN7868325
发货至:
中国
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Quick Overview for TTC36 抗体 (AA 1-187) (ABIN7868325)
抗原
TTC36
(Tetratricopeptide Repeat Domain 36 (TTC36))
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
This TTC36 antibody is un-conjugated
应用范围
ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
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抗原表位
- AA 1-187
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原理
- TTC36 Antibody / Tetratricopeptide repeat protein 36
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human TTC36 recombinant protein (Position: M1-D187) was used as the immunogen for the TTC36 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the TTC36 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TTC36 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TTC36 (Tetratricopeptide Repeat Domain 36 (TTC36))
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别名
- TTC36
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背景
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TTC36 antibody detects Tetratricopeptide repeat protein 36, a cytoplasmic protein containing multiple TPR motifs that mediate protein-protein interactions involved in cellular signaling and structural organization. The UniProt recommended name is Tetratricopeptide repeat protein 36 (TTC36). Although not fully characterized, TTC36 is believed to function as a molecular scaffold, facilitating the assembly of multiprotein complexes that regulate cell differentiation and signal transduction.
Functionally, TTC36 antibody identifies a 356-amino-acid protein rich in tetratricopeptide repeat sequences, which serve as recognition modules for chaperones and signaling enzymes. TTC36 interacts with cytoskeletal and membrane-associated proteins, suggesting roles in maintaining cell integrity and coordinating intracellular signaling. Its TPR domains likely promote conformational flexibility, enabling diverse binding partners.
The TTC36 gene is located on chromosome 6q22.33 and is expressed in epithelial tissues, gastrointestinal tract, and reproductive organs. Gene expression analyses indicate regulation by Wnt and TGF-beta pathways, implicating TTC36 in developmental and oncogenic signaling. Its expression in enterocytes and hepatocytes supports potential functions in nutrient transport or cellular adhesion.
Pathologically, altered TTC36 expression has been reported in several cancers, including hepatocellular carcinoma and gastric cancer, where its downregulation correlates with increased tumor growth and metastasis. TTC36 is thought to act as a tumor suppressor by modulating signaling cascades that control cell proliferation and adhesion. Research with TTC36 antibody aids in exploring these molecular interactions and their impact on cancer progression.
TTC36 antibody is suitable for western blotting, immunohistochemistry, and immunofluorescence to detect cytoplasmic TPR-containing scaffolds. NSJ Bioreagents offers TTC36 antibody reagents validated for studies of protein complex assembly, signaling regulation, and epithelial cell biology.
Structurally, TTC36 features tandem TPR motifs that create a solenoid-like architecture, enabling multipoint interactions with diverse proteins. This antibody supports detailed investigations into TTC36's scaffolding roles in intracellular communication and cancer biology. -
UniProt
- A6NLP5
抗原
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