RSL24D1 抗体 (AA 1-163)
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Quick Overview for RSL24D1 抗体 (AA 1-163) (ABIN7868228)
抗原
See all RSL24D1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-163
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原理
- RSL24D1 Antibody / Ribosomal L24 domain-containing protein 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human RSL24D1 recombinant protein (Position: M1-P163) was used as the immunogen for the RSL24D1 antibody.
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亚型
- IgG
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anti-Ribosomal L24 Domain Containing 1 (RSL24D1) (AA 1-150) antibody
RSL24D1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2A10-1E5 unconjugated
anti-Ribosomal L24 Domain Containing 1 (RSL24D1) (AA 1-151) antibodyRSL24D1 适用: 人 WB, ELISA, IF, IHC (p), IHC 宿主: 小鼠 Monoclonal 2A10-1E5 unconjugated
anti-Ribosomal L24 Domain Containing 1 (RSL24D1) (C-Term) antibodyRSL24D1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, Hamster, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal L24 Domain Containing 1 (RSL24D1) (AA 35-84) antibodyRSL24D1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal L24 Domain Containing 1 (RSL24D1) (AA 10-80) antibodyRSL24D1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal L24 Domain Containing 1 (RSL24D1) (Middle Region) antibodyRSL24D1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Saccharomyces cerevisiae, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the RSL24D1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the RSL24D1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- RSL24D1 (Ribosomal L24 Domain Containing 1 (RSL24D1))
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别名
- RSL24D1
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背景
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RSL24D1 antibody detects Ribosomal L24 domain-containing protein 1, a nucleolar factor involved in ribosome biogenesis and pre-rRNA processing. The UniProt recommended name is Ribosomal L24 domain-containing protein 1 (RSL24D1). This protein plays a key role in the maturation of the large 60S ribosomal subunit and the assembly of functional ribosomes necessary for protein synthesis and cell growth.
Functionally, RSL24D1 antibody identifies a 332-amino-acid nucleolar protein that associates with preribosomal complexes during 60S subunit assembly. RSL24D1 interacts with rRNA intermediates and ribosomal proteins to facilitate cleavage and folding events required for ribosome maturation. It participates in the late steps of rRNA processing, ensuring proper incorporation of 28S rRNA into the large subunit. RSL24D1 is functionally conserved across eukaryotes, underscoring its central role in ribosome biogenesis.
The RSL24D1 gene is located on chromosome 15q25.2 and is expressed in proliferative tissues such as bone marrow, testis, and liver, where active ribosome production supports rapid cell growth. Expression levels correlate with translational demand and are tightly controlled by growth factor and nutrient signaling pathways that regulate ribosome assembly.
Pathologically, dysregulation of RSL24D1 affects ribosomal homeostasis and has been linked to cancer and ribosomopathies. Overexpression promotes cell proliferation and is associated with tumor growth, while loss of function leads to impaired ribosome production and nucleolar stress. RSL24D1 interacts with tumor suppressor pathways, including p53 activation in response to ribosomal imbalance. Research using RSL24D1 antibody supports studies in translation regulation, cancer biology, and ribosome assembly mechanisms.
RSL24D1 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect nucleolar ribosome assembly proteins. NSJ Bioreagents provides RSL24D1 antibody reagents optimized for research in RNA processing, ribosome maturation, and cell proliferation control.
Structurally, Ribosomal L24 domain-containing protein 1 contains a conserved L24-like domain characteristic of large ribosomal subunit proteins, facilitating interactions with rRNA and assembly factors. Its C-terminal region mediates nucleolar localization and binding to preribosomal complexes. This antibody enables detailed investigation of RSL24D1's role in ribosome biogenesis, translational control, and cellular growth regulation. -
UniProt
- Q9UHA3
抗原
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