GLIPR2 抗体 (AA 1-154)
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Quick Overview for GLIPR2 抗体 (AA 1-154) (ABIN7868212)
抗原
See all GLIPR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-154
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原理
- GLIPR2 Antibody / GLI pathogenesis-related protein 2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human GLIPR2 recombinant protein (Position: M1-K154) was used as the immunogen for the GLIPR2 antibody.
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亚型
- IgG
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anti-GLI Pathogenesis-Related 2 (GLIPR2) (AA 1-154) antibody
GLIPR2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-GLI Pathogenesis-Related 2 (GLIPR2) (AA 2-85) antibodyGLIPR2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-GLI Pathogenesis-Related 2 (GLIPR2) (AA 1-30), (N-Term) antibodyGLIPR2 适用: 人 WB 宿主: 兔 Polyclonal RB25221 unconjugated
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应用备注
- Optimal dilution of the GLIPR2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GLIPR2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GLIPR2 (GLI Pathogenesis-Related 2 (GLIPR2))
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别名
- GLIPR2
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背景
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GLIPR2 antibody detects GLI pathogenesis-related protein 2, a member of the pathogenesis-related (PR-1) protein superfamily implicated in autophagy regulation, cellular stress response, and tumor progression. The UniProt recommended name is GLI pathogenesis-related protein 2 (GLIPR2), also known as Golgi-associated plant pathogenesis-related protein 1 domain-containing protein 2 (GAPR-1). GLIPR2 is a lipid raft-associated protein predominantly localized to the Golgi apparatus and cytoplasmic membranes, where it contributes to membrane homeostasis and cell survival pathways.
Functionally, GLIPR2 antibody recognizes a 172-amino-acid protein that plays a dual role in regulating autophagy and cellular differentiation. GLIPR2 interacts with Beclin-1, a central component of the autophagy initiation complex, to modulate autophagosome formation. Overexpression of GLIPR2 inhibits autophagic flux, whereas its depletion enhances autophagy under stress conditions. This regulatory balance links GLIPR2 to processes such as tumor suppression, cell death, and immune modulation. The protein is expressed in multiple tissues, including liver, kidney, and lung, and its expression is inducible under oxidative or endoplasmic reticulum stress.
The GLIPR2 gene is located on chromosome 9p13.3 and encodes a secreted and membrane-associated protein characterized by a conserved CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1) domain. This structural motif enables interactions with lipids, membranes, and signaling proteins, mediating responses to cellular stress. GLIPR2 is known to form homodimers and is subject to regulation by cholesterol content in the Golgi membrane. This localization allows it to influence vesicle trafficking and protein processing under metabolic challenge.
GLIPR2 antibody is widely used in research investigating autophagy, lipid homeostasis, and tumor biology. In cancer studies, GLIPR2 functions as a modulator of epithelial-to-mesenchymal transition (EMT), influencing cell adhesion, migration, and invasion. Dysregulated GLIPR2 expression has been linked to aggressive tumor phenotypes, including hepatocellular carcinoma and renal cell carcinoma. In non-cancer contexts, GLIPR2 participates in innate immune regulation and Golgi stress adaptation. It also contributes to lung tissue integrity by modulating surfactant secretion and inflammatory signaling.
At the molecular level, GLIPR2 interacts with proteins involved in oxidative stress response and chaperone-assisted folding. Its CAP domain facilitates binding to phosphatidylinositol lipids, anchoring it to specific membrane compartments. The GLIPR2 antibody is an essential tool for detecting this protein in cell biology, immunofluorescence, and immunoblotting applications. Its detection assists in understanding Golgi function, autophagy balance, and membrane organization under normal and pathological conditions.
NSJ Bioreagents provides GLIPR2 antibody reagents validated for use in autophagy, oncology, and membrane biology research, supporting studies of stress signaling and intracellular trafficking mechanisms. -
UniProt
- Q9H4G4
抗原
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