C6orf130 抗体 (AA 1-152)
This 兔 多克隆 antibody specifically detects C6orf130 in WB, ELISA, IHC, ICC, FACS 和 IF. It exhibits reactivity toward 人, 小鼠 和 大鼠.
产品编号 ABIN7868195
发货至:
中国
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Quick Overview for C6orf130 抗体 (AA 1-152) (ABIN7868195)
抗原
See all C6orf130 (OARD1) 抗体
C6orf130 (OARD1)
(O-Acyl-ADP-Ribose Deacylase 1 (OARD1))
适用
人, 小鼠, 大鼠
宿主
兔
克隆类型
多克隆
标记
This C6orf130 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (IF)
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抗原表位
- AA 1-152
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原理
- OARD1 Antibody / O-acetyl-ADP-ribose deacetylase 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human C6orf130/OARD1 recombinant protein (Position: M1-L152) was used as the immunogen for the OARD1 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the OARD1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the OARD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- C6orf130 (OARD1) (O-Acyl-ADP-Ribose Deacylase 1 (OARD1))
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别名
- OARD1
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背景
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OARD1 antibody detects ADP-ribose glycohydrolase OARD1, encoded by the OARD1 gene on chromosome 6q14.2. OARD1 antibody is used in research on ADP-ribosylation, DNA repair, and chromatin biology. OARD1 is an enzyme that removes ADP-ribose from proteins, acting as a mono-ADP-ribosylhydrolase. This activity counteracts PARP-mediated ADP-ribosylation, a key post-translational modification involved in DNA repair, transcription, and stress signaling.
Structurally, OARD1 is a ~17 kDa protein containing a macrodomain, which mediates binding and hydrolysis of ADP-ribose groups. The macrodomain recognizes ADP-ribosylated substrates and catalyzes removal of the modification. OARD1 localizes to the nucleus, where it associates with chromatin and DNA repair complexes. Isoforms generated by alternative splicing provide additional regulatory functions.
Functionally, OARD1 regulates chromatin dynamics and DNA repair by reversing mono-ADP-ribosylation on histones and DNA repair proteins. This counter-regulation maintains genomic stability and prevents accumulation of aberrant ADP-ribose modifications. Knockdown of OARD1 leads to DNA damage sensitivity, chromatin defects, and altered transcription. Researchers use OARD1 antibody to study ADP-ribosylation signaling, chromatin regulation, and DNA repair pathways.
Clinically, OARD1 has been implicated in cancer and neurodegeneration. Altered ADP-ribosylation dynamics contribute to oncogenesis by disrupting DNA repair and transcriptional regulation. OARD1 may also influence response to PARP inhibitors, which are used to treat BRCA-deficient tumors. Mutations or dysregulation of OARD1 have been linked to neurological disorders involving DNA damage accumulation. NSJ Bioreagents provides OARD1 antibody to support cancer, neurology, and epigenetics research.
Experimentally, OARD1 antibody is used in western blotting to detect the ~17 kDa protein, in immunohistochemistry to study nuclear expression, and in chromatin immunoprecipitation to examine ADP-ribosylation regulation. Co-immunoprecipitation with OARD1 antibody identifies partners including PARP family members and DNA repair proteins. -
UniProt
- Q9Y530
抗原
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