CEBPG 抗体 (AA 1-150)
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Quick Overview for CEBPG 抗体 (AA 1-150) (ABIN7868182)
抗原
See all CEBPG 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-150
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原理
- CEBPG Antibody / CCAAT/enhancer-binding protein gamma
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human CEBPG recombinant protein (Position: M1-Q150) was used as the immunogen for the CEBPG antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the CEBPG antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the CEBPG antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- CEBPG (CCAAT/enhancer Binding Protein (C/EBP), gamma (CEBPG))
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别名
- CEBPG
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背景
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CEBPG antibody targets CCAAT/enhancer-binding protein gamma, a member of the CEBP family of transcription factors that regulate genes involved in immune response, metabolism, and cell differentiation. CEBPG lacks a canonical transactivation domain and instead acts as a dimerization partner for other CEBP family members such as CEBPA, CEBPB, and CEBPD, influencing transcription through heterodimer formation. This modulatory activity enables CEBPG to fine-tune expression of genes associated with inflammation, DNA repair, and oxidative stress responses. The protein is localized primarily in the nucleus, where it binds to CCAAT motifs within promoter regions and modulates transcriptional outcomes depending on its dimerization partner.
CEBPG is encoded by the CEBPG gene located on chromosome 19q13.11 and produces a protein of approximately 15 kilodaltons. It is ubiquitously expressed but particularly abundant in immune cells, liver, and lung tissues. Through interaction with CEBPB, CEBPG contributes to the regulation of cytokine expression, lipid metabolism, and acute phase responses. In addition to its transcriptional role, CEBPG has been linked to DNA damage tolerance pathways, where it may cooperate with ATF4 to activate antioxidant genes during cellular stress. The CEBPG antibody is therefore widely used in studies of transcriptional regulation, inflammation, and stress response signaling.
Research indicates that CEBPG participates in regulatory networks controlling macrophage activation and epithelial defense responses. Overexpression or silencing of CEBPG affects the expression of downstream effectors such as SOD2, GPX1, and TNF, linking this factor to redox balance and inflammatory signaling. Because of its cooperative interactions with other CEBP proteins, CEBPG serves as an important hub in transcriptional cascades influencing differentiation and immune adaptation. The CEBPG antibody is validated for western blotting, immunofluorescence, and chromatin immunoprecipitation assays, enabling analysis of protein expression and DNA-binding activity. NSJ Bioreagents provides this antibody for researchers studying gene regulation, stress adaptation, and cellular defense mechanisms. -
UniProt
- P53567
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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