FHIT 抗体 (AA 1-147)
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Quick Overview for FHIT 抗体 (AA 1-147) (ABIN7868171)
抗原
See all FHIT 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-147
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原理
- FHIT Antibody
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纯化方法
- Protein G affinity
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免疫原
- Human FHIT recombinant protein (amino acids M1-Q147) was used as the immunogen for the FHIT antibody antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the FHIT antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the FHIT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- FHIT (Fragile Histidine Triad (FHIT))
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别名
- FHIT
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背景
- Bis(5'-adenosyl)-triphosphatase, also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene. This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3p14.2, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Furthermore, FHIT has been shown to synergize with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. It also acts as a tumor suppressor of HER2/neu driven breast cancer.
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UniProt
- P49789
抗原
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