THRSP 抗体 (AA 1-146)
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北京 101111
Quick Overview for THRSP 抗体 (AA 1-146) (ABIN7868170)
抗原
See all THRSP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-146
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原理
- THRSP Antibody / Thyroid hormone-responsive protein
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human THRSP recombinant protein (Position: M1-W146) was used as the immunogen for the THRSP antibody.
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亚型
- IgG
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anti-Thyroid Hormone Responsive (THRSP) (AA 1-146) antibody
THRSP 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Responsive (THRSP) (AA 1-84) antibodyTHRSP 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2F8 unconjugated
anti-Thyroid Hormone Responsive (THRSP) (AA 41-144) antibodyTHRSP 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Responsive (THRSP) (AA 1-146) antibodyTHRSP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Responsive (THRSP) (AA 116-145) antibodyTHRSP 适用: 人, 大鼠 ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Responsive (THRSP) (AA 18-48) antibodyTHRSP 适用: 人 WB 宿主: 兔 Polyclonal RB54698 unconjugated
anti-Thyroid Hormone Responsive (THRSP) antibodyTHRSP 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Responsive (THRSP) (AA 1-150) antibodyTHRSP 适用: 小鼠 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Thyroid Hormone Responsive (THRSP) antibodyTHRSP 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the THRSP antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the THRSP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- THRSP (Thyroid Hormone Responsive (THRSP))
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别名
- THRSP
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背景
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THRSP antibody detects Thyroid hormone-responsive protein, encoded by the THRSP gene on chromosome 11q13.5. THRSP antibody is widely applied in studies of lipid metabolism, endocrine regulation, and cancer biology. THRSP, also known as Spot14, is a nuclear protein induced by thyroid hormone and carbohydrate feeding. It is highly expressed in liver, adipose tissue, and lactating mammary gland, where it regulates lipogenesis by controlling transcription of lipogenic enzymes. In humans, THRSP expression correlates with metabolic state and hormonal regulation, making it a valuable marker for metabolic research.
Structurally, THRSP is a ~17 kDa acidic nuclear protein that lacks enzymatic activity but functions as a transcriptional regulator. It contains nuclear localization sequences and DNA-binding domains that interact with chromatin and transcription factors. Its regulation is tightly linked to nutritional and hormonal status, with strong induction by triiodothyronine (T3), glucose, and insulin.
Functionally, THRSP promotes lipogenesis by enhancing expression of genes such as fatty acid synthase and acetyl-CoA carboxylase. It plays an important role in lactation, where increased lipogenesis supports milk production. In liver, THRSP regulates triglyceride synthesis and influences lipid storage. Overexpression of THRSP drives lipid accumulation, while deficiency impairs lipid biosynthesis. Researchers use THRSP antibody to investigate lipid metabolism, endocrine signaling, and mammary gland physiology.
Clinically, THRSP is associated with metabolic diseases and cancer. Dysregulated THRSP expression contributes to obesity, fatty liver disease, and breast cancer. Elevated expression in breast tumors correlates with lipogenic phenotype and worse prognosis. As a hormone-responsive gene, THRSP also serves as a biomarker of thyroid hormone activity and metabolic adaptation. NSJ Bioreagents provides THRSP antibody for studies in metabolism, endocrinology, and oncology.
Experimentally, THRSP antibody is used in western blotting to detect the ~17 kDa protein, in immunohistochemistry to study expression in liver and mammary gland, and in immunofluorescence to analyze nuclear localization. Co-immunoprecipitation with THRSP antibody identifies chromatin-associated complexes involved in lipogenic gene regulation. -
UniProt
- Q92748
抗原
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