ATOH7 抗体 (AA 1-134)
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Quick Overview for ATOH7 抗体 (AA 1-134) (ABIN7868103)
抗原
See all ATOH7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-134
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原理
- Zebrafish Atoh7 Antibody / Lakritz
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Atoh7 recombinant protein (amino acids M1-L134) was used as the immunogen for the Zebrafish Atoh7 antibody.
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亚型
- Ig Fraction
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anti-Atonal Homolog 7 (ATOH7) (AA 53-99) antibody
ATOH7 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A5 unconjugated
anti-Atonal Homolog 7 (ATOH7) (AA 1-152) antibodyATOH7 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Atonal Homolog 7 (ATOH7) (AA 1-152) antibodyATOH7 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Atonal Homolog 7 (ATOH7) antibodyATOH7 适用: 人 IF 宿主: 兔 Polyclonal unconjugated
anti-Atonal Homolog 7 (ATOH7) (AA 47-152) antibodyATOH7 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Atonal Homolog 7 (ATOH7) (AA 85-112) antibodyATOH7 适用: 人 WB 宿主: 兔 Polyclonal RB42355 unconjugated
anti-Atonal Homolog 7 (ATOH7) (C-Term) antibodyATOH7 适用: 人, Cow, 犬, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Zebrafish Atoh7 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Atoh7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- ATOH7 (Atonal Homolog 7 (ATOH7))
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别名
- Atoh7
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背景
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Atonal homolog 7 (Atoh7), also known as Lakritz, is a basic helix-loop-helix (bHLH) transcription factor that plays an essential role in retinal neurogenesis, particularly in the specification of retinal ganglion cells (RGCs). In zebrafish (Danio rerio), Atoh7 is critical for the early stages of eye development, where it governs the differentiation of progenitor cells into RGCs-the first retinal neurons to extend axons to the brain.
During zebrafish embryogenesis, atoh7 is expressed in retinal progenitor cells, and its activity initiates the genetic cascade required for RGC formation and optic nerve development. Mutations in atoh7, such as in the lakritz mutant, result in the complete absence of RGCs and a failure to form the optic nerve, making it a key model for studying retinal development, axonal pathfinding, and neuronal lineage commitment.
Given its conserved function across vertebrates, zebrafish Atoh7 is widely used in research on eye development, stem cell differentiation, and regenerative medicine targeting visual system repair. It also serves as a molecular marker for early neurogenesis in the retina.
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UniProt
- Q8AW52
抗原
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