MYOD1 抗体 (AA 1-120)
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Quick Overview for MYOD1 抗体 (AA 1-120) (ABIN7868018)
抗原
See all MYOD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-120
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原理
- MYOD1 Antibody / Myoblast determination protein 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human MYOD1 recombinant protein (Position: M1-R120) was used as the immunogen for the MYOD1 antibody.
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亚型
- IgG
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anti-Myogenic Differentiation 1 (MYOD1) (AA 150-250) antibody
MYOD1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Myogenic Differentiation 1 (MYOD1) (AA 51-150) antibodyMYOD1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Myogenic Differentiation 1 (MYOD1) antibodyMYOD1 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal rMYD712 unconjugated Recombinant Antibody
anti-Myogenic Differentiation 1 (MYOD1) antibodyMYOD1 适用: 人, 小鼠, 大鼠, 豚鼠, Hamster, 兔 WB, IHC 宿主: 兔 Monoclonal MYOD1-2075R unconjugated Recombinant Antibody
anti-Myogenic Differentiation 1 (MYOD1) (AA 1-320) antibodyMYOD1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myogenic Differentiation 1 (MYOD1) (AA 211-240) antibodyMYOD1 适用: 人 WB, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Myogenic Differentiation 1 (MYOD1) (AA 211-320) antibodyMYOD1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Myogenic Differentiation 1 (MYOD1) (AA 211-320) antibodyMYOD1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A7 unconjugated
anti-Myogenic Differentiation 1 (MYOD1) antibodyMYOD1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-Myogenic Differentiation 1 (MYOD1) (AA 211-240) antibodyMYOD1 适用: 人 WB, IF 宿主: 兔 Polyclonal RB18817 unconjugated
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应用备注
- Optimal dilution of the MYOD1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MYOD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MYOD1 (Myogenic Differentiation 1 (MYOD1))
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别名
- MYOD1
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背景
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MYOD1 antibody detects Myoblast determination protein 1, a master transcription factor that controls skeletal muscle differentiation. The UniProt recommended name is Myoblast determination protein 1 (MYOD1). This basic helix-loop-helix (bHLH) transcription factor binds DNA at E-box motifs to activate muscle-specific gene expression, converting multipotent mesodermal cells into myoblasts.
Functionally, MYOD1 antibody identifies a 320-amino-acid nuclear protein that dimerizes with E proteins to regulate the transcription of myogenic regulatory genes such as MYOG and MYF5. MYOD1 acts as a pioneer factor, remodeling chromatin to establish muscle-specific transcriptional programs. It is indispensable for myogenic lineage commitment and muscle regeneration following injury.
The MYOD1 gene is located on chromosome 11p15.1 and is expressed in skeletal muscle progenitor cells and differentiating myoblasts. MYOD1 operates in coordination with MEF2 family transcription factors to control muscle fiber formation and repair. During development, its expression defines the onset of the myogenic program.
Pathologically, MYOD1 dysregulation is associated with muscle developmental disorders and certain sarcomas. Mutations in MYOD1 have been identified in rhabdomyosarcoma, where aberrant transcriptional activation promotes tumorigenesis. Research using MYOD1 antibody supports studies in muscle development, differentiation, and cancer biology.
MYOD1 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect myogenic transcription factors. NSJ Bioreagents provides MYOD1 antibody reagents optimized for skeletal muscle biology, stem cell differentiation, and gene regulation research.
Structurally, Myoblast determination protein 1 contains a bHLH domain that mediates DNA binding and dimerization. Its N-terminal activation domain recruits chromatin remodeling complexes to activate transcription. This antibody facilitates detailed examination of MYOD1's regulatory network in muscle cell fate determination. -
UniProt
- P15172
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途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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