GALP 抗体 (AA 1-116)
This 兔 多克隆 antibody specifically detects GALP in ELISA 和 WB. It exhibits reactivity toward 人, 大鼠 和 小鼠.
产品编号 ABIN7867970
发货至:
中国
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Quick Overview for GALP 抗体 (AA 1-116) (ABIN7867970)
抗原
See all GALP 抗体
GALP
(Galanin-Like Peptide (GALP))
适用
人, 大鼠, 小鼠
宿主
兔
克隆类型
多克隆
标记
This GALP antibody is un-conjugated
应用范围
ELISA, Western Blotting (WB)
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抗原表位
- AA 1-116
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原理
- GALP Antibody / Galanin-like peptide
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human GALP recombinant protein (Position: M1-S116) was used as the immunogen for the GALP antibody.
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亚型
- IgG
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anti-Galanin-Like Peptide (GALP) antibody
GALP 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Galanin-Like Peptide (GALP) (AA 29-115) antibodyGALP 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the GALP antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the GALP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- GALP (Galanin-Like Peptide (GALP))
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别名
- GALP
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背景
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GALP antibody detects Galanin-like peptide, a hypothalamic neuropeptide involved in energy balance, feeding behavior, and reproductive hormone regulation. The UniProt recommended name is Galanin-like peptide (GALP). This neuropeptide acts within the central nervous system to integrate metabolic, thermoregulatory, and neuroendocrine signals, linking energy status to reproductive function and stress adaptation.
Functionally, GALP antibody identifies a 60-amino-acid peptide derived from a larger precursor encoded by the GALP gene. The peptide binds to galanin receptors GALR1, GALR2, and GALR3, activating G protein-mediated signaling pathways that influence neuronal excitability and neuroendocrine secretion. GALP is expressed primarily in the arcuate nucleus and median eminence of the hypothalamus, where it regulates appetite, body temperature, and pituitary hormone release. Its expression is modulated by leptin, insulin, and circulating glucose levels, positioning GALP as a metabolic signal integrator.
The GALP gene is located on chromosome 19q13.43 and exhibits conserved expression in mammals, reflecting its importance in metabolic control. GALP neurons project to hypothalamic and extrahypothalamic regions involved in feeding and thermoregulation, including the paraventricular nucleus and dorsal raphe.
Pathologically, dysregulation of GALP signaling contributes to metabolic and neuroendocrine disorders such as obesity, infertility, and hypothalamic dysfunction. Reduced GALP expression is associated with leptin deficiency and disrupted reproductive cycling, while elevated levels influence energy expenditure and thermogenesis. Research using GALP antibody supports studies in neuroendocrinology, energy metabolism, and reproductive physiology.
GALP antibody is validated for immunohistochemistry, immunofluorescence, and ELISA to detect neuropeptides in hypothalamic and pituitary tissues. NSJ Bioreagents provides GALP antibody reagents optimized for studies in appetite regulation, metabolic homeostasis, and stress signaling.
Structurally, Galanin-like peptide shares sequence homology with galanin in its N-terminal region, allowing interaction with the same receptor family but with distinct potency and distribution. Post-translational processing of prepro-GALP yields the mature peptide with amidated C-terminus essential for receptor activation. This antibody enables analysis of GALP's role in central metabolic control and neuroendocrine integration. -
UniProt
- Q9UBC7
抗原
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