PVALB 抗体 (AA 1-110)
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北京 101111
Quick Overview for PVALB 抗体 (AA 1-110) (ABIN7867944)
抗原
See all PVALB 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-110
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原理
- Parvalbumin Antibody / PVALB
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant partial protein sequence (within amino acids 1-110) from the human protein was used as the immunogen for the Parvalbumin antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the Parvalbumin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Parvalbumin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- PVALB (Parvalbumin (PVALB))
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别名
- Parvalbumin
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背景
- The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca2+-binding protein), S-100Alpha and beta, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins) and the parvalbumin family members, including parvalbumin Alpha and parvalbumin beta, also designated oncomodulin (OCM). Structurally and evolutionarily conserved, parvalbumin Alpha and OCM proteins are distinct in expression and function. Parvalbumin Alpha, also designated parvalbumin (PV), is most abundantly expressed in fast-contracting muscles with lower expression levels in brain and some endocrine tissues, including kidney and parathyroid. Research indicates that parvalbumin Alpha plays a significant role in muscle relaxation. OCM was originally thought to have expression restricted to neoplastic tissues, early embryonic cells and certain tumor cell lines. Recent research shows that OCM is also expressed and secreted by macrophages where, in the retina it binds to retinal ganglion cells (RGCs) and functions to promote axon regeneration. OCM has also been detected in the auditory sensory cells of the organ of Corti in mammals. In humans, two different loci on chromosome 7 have been identified as OCM and OCM-like (LOC4951). These genes encode proteins 109 amino acids in length which share 99 % sequence identity.
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UniProt
- P20472
抗原
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