FYCO1 抗体 (AA 1-1019)
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北京 101111
Quick Overview for FYCO1 抗体 (AA 1-1019) (ABIN7867920)
抗原
See all FYCO1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-1019
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原理
- FYCO1 Antibody / FYVE and coiled-coil domain containing 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human FYCO1 recombinant protein (Position: M1-K1019) was used as the immunogen for the FYCO1 antibody.
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亚型
- IgG
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anti-FYVE and Coiled-Coil Domain Containing 1 (FYCO1) (AA 1-255) antibody
FYCO1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-FYVE and Coiled-Coil Domain Containing 1 (FYCO1) (Internal Region) antibodyFYCO1 适用: 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FYVE and Coiled-Coil Domain Containing 1 (FYCO1) (AA 2-255) antibodyFYCO1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-FYVE and Coiled-Coil Domain Containing 1 (FYCO1) (AA 1051-1150) antibodyFYCO1 适用: 人, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the FYCO1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the FYCO1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- FYCO1 (FYVE and Coiled-Coil Domain Containing 1 (FYCO1))
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别名
- FYCO1
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背景
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FYCO1 antibody detects FYVE and coiled-coil domain containing 1, encoded by the FYCO1 gene. FYVE and coiled-coil domain containing 1 is a cytoplasmic protein that functions as an autophagy adaptor, linking autophagosomes to microtubule-based transport systems. FYCO1 antibody provides researchers with a key reagent for studying autophagy, vesicle trafficking, and disease mechanisms involving impaired cellular clearance.
FYVE and coiled-coil domain containing 1 contains a FYVE domain that binds phosphatidylinositol-3-phosphate on autophagosome membranes and a LC3-interacting region that recruits autophagy machinery. Research using FYCO1 antibody has shown that the protein couples autophagosomes to kinesin motors, promoting their transport along microtubules toward the cell periphery. This process facilitates autophagosome maturation and fusion with lysosomes.
Studies with FYCO1 antibody have revealed that loss-of-function mutations in FYCO1 cause autosomal recessive congenital cataracts. In lens epithelial cells, defective autophagy due to impaired FYCO1 activity leads to accumulation of damaged proteins and organelles, resulting in lens opacity. This genetic association highlights the clinical relevance of FYCO1 in ocular development and disease.
Dysregulation of FYVE and coiled-coil domain containing 1 has also been implicated in neurodegeneration and infection. Research using FYCO1 antibody has shown that altered expression affects autophagosome trafficking in neurons, contributing to accumulation of aggregates in neurodegenerative conditions. Pathogens such as Mycobacterium tuberculosis can manipulate FYCO1-mediated pathways, underscoring its significance in host-pathogen interactions.
FYCO1 antibody is widely applied in immunofluorescence, immunohistochemistry, and western blotting. Immunofluorescence highlights co-localization with LC3-positive autophagosomes, immunohistochemistry demonstrates tissue-specific expression, and western blotting quantifies levels in cells and tissues. These applications make FYCO1 antibody indispensable in autophagy and vesicle transport research.
By providing validated FYCO1 antibody reagents, NSJ Bioreagents supports studies into autophagy, cellular clearance, and disease. Detection of FYVE and coiled-coil domain containing 1 provides researchers with insight into how adaptor proteins regulate vesicle trafficking and pathology. -
UniProt
- Q9BQS8
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途径
- SARS-CoV-2 Protein Interactome
抗原
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