Recombinant MYOD1 抗体 (AA 1-100)
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Quick Overview for Recombinant MYOD1 抗体 (AA 1-100) (ABIN7867874)
抗原
See all MYOD1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-100
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原理
- Recombinant Myoblast determination protein 1 Antibody / MyoD1
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant fragment (within amino acids 1-100) of human MyoD1 protein was used as the immunogen for the recombinant Myoblast determination protein 1 antibody.
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亚型
- IgG, kappa
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应用备注
- Optimal dilution of the recombinant Myoblast determination protein 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant Myoblast determination protein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- MYOD1 (Myogenic Differentiation 1 (MYOD1))
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别名
- Myoblast determination protein 1
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背景
- MyoD1, one of the MyoD family of myogenic helix-loop-helix transcription factors, combined with myogenin, plays a role in coordinating the myogenic differentiation pathway from the determination of mesodermal precursors into myoblasts, the differentiation of myoblasts into myotubes, and finally the maturation of myotubes into skeletal myofibers. Normal mature skeletal muscle does not express MyoD1 protein. MyoD1 is expressed in myoblasts before differentiation while myogenin has post-differentiation functions. Anti-MyoD1 immunostaining identifies cells committed to myogenesis in their earliest phase, thus, it is a better biomarker for less differentiated Rhabdomyosarcomas (RMS). RMS are the most frequent malignant soft tissue neoplasms of childhood. While better differentiated RMS have cross-striations or rhabdomyoblasts that allow for a confident morphologic diagnosis, less differentiated RMS resemble other small blue round-cell tumors. Studies suggest, anti-MyoD1 may be used together with anti-Myogenin and anti-Desmin as a panel of markers since any RMS is virtually never negative for all three markers simultaneously.
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UniProt
- P15172
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途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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