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Recombinant MYOD1 抗体 (AA 1-100)

This 兔 单克隆 antibody specifically detects MYOD1 in IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN7867874
发货至: 中国
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Quick Overview for Recombinant MYOD1 抗体 (AA 1-100) (ABIN7867874)

抗原

See all MYOD1 抗体
MYOD1 (Myogenic Differentiation 1 (MYOD1))

抗体类型

Recombinant Antibody

适用

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宿主

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克隆类型

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单克隆

标记

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This MYOD1 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

MYOD1-9405R
  • 抗原表位

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    AA 1-100

    原理

    Recombinant Myoblast determination protein 1 Antibody / MyoD1

    纯化方法

    Protein A/G affinity

    免疫原

    A recombinant fragment (within amino acids 1-100) of human MyoD1 protein was used as the immunogen for the recombinant Myoblast determination protein 1 antibody.

    亚型

    IgG, kappa
  • 应用备注

    Optimal dilution of the recombinant Myoblast determination protein 1 antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the recombinant Myoblast determination protein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    MYOD1 (Myogenic Differentiation 1 (MYOD1))

    别名

    Myoblast determination protein 1

    背景

    MyoD1, one of the MyoD family of myogenic helix-loop-helix transcription factors, combined with myogenin, plays a role in coordinating the myogenic differentiation pathway from the determination of mesodermal precursors into myoblasts, the differentiation of myoblasts into myotubes, and finally the maturation of myotubes into skeletal myofibers. Normal mature skeletal muscle does not express MyoD1 protein. MyoD1 is expressed in myoblasts before differentiation while myogenin has post-differentiation functions. Anti-MyoD1 immunostaining identifies cells committed to myogenesis in their earliest phase, thus, it is a better biomarker for less differentiated Rhabdomyosarcomas (RMS). RMS are the most frequent malignant soft tissue neoplasms of childhood. While better differentiated RMS have cross-striations or rhabdomyoblasts that allow for a confident morphologic diagnosis, less differentiated RMS resemble other small blue round-cell tumors. Studies suggest, anti-MyoD1 may be used together with anti-Myogenin and anti-Desmin as a panel of markers since any RMS is virtually never negative for all three markers simultaneously.

    UniProt

    P15172

    途径

    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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