VCAM1 抗体
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北京 101111
Quick Overview for VCAM1 抗体 (ABIN7865753)
抗原
See all VCAM1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- anti-CD106 mouse monoclonal, B-K9, purified
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纯化方法
- affinity chromatography
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免疫原
- activated umbilical cord vein endothelial cells (HUVEC)
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亚型
- IgG1 kappa
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应用备注
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ICC/IF_dilution: 1:100-1:200 (0.5-1.0 μg/mL)
FACS_dilution: 0.5-1.0 μg/million cells in 0.1 ml
IHC-frozen_dilution: 1:50-1:100 (1-2 μg/mL)
elisa_dilution: assay dependent
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 100 μg/mL
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缓冲液
- PBS with 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- store at 2 - 8 °C
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- VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))
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别名
- CD106
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背景
- CD106 is a protein of 110 kDa, also known as vascular cell adhesion molecule-1 (VCAM-1) and INCAM-100. CD106 is a member of the Ig superfamily of adhesion molecules and is expressed at high levels on cytokine stimulated vascular endothelial cells, and at minimal levels on un-stimulated endothelial cells. It is also present on follicular dendritic cells of lymph nodes, myoblasts, and some macrophages. In addition, epithelial cells and cancers cells can be positive, like in kidney and prostate cancer. CD106 serves as a ligand for leukocytes integrin (VLA-4 or CD49d/CD29) and mediates cell adhesion of leukocytes to activated endothelium. It plays a role in various immunological and inflammatory responses. B-K9 inhibits the binding of leukocytes to VCAM-1 on stimulated endothelial cells. Positive control: Human placenta or tonsil, kidney, some prostate cancers.
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途径
- Carbohydrate Homeostasis
抗原
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