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CD109 抗体

The 小鼠 单克隆 anti-CD109 antibody (Clone EBS-CD-046) (ABIN7865575) specifically detects CD109 in IHC, ICC, FACS 和 IF. The antibody is reactive with 人 和 猴 samples.
产品编号 ABIN7865575
发货至: 中国
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for CD109 抗体 (ABIN7865575)

抗原

See all CD109 抗体
CD109

适用

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人, 猴

宿主

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小鼠

克隆类型

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  • 1
单克隆

标记

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This CD109 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (IF)

克隆位点

EBS-CD-046
  • 原理

    anti-CD109 mouse monoclonal, EBS-CD-046, purified

    纯化方法

    affinity chromatography

    免疫原

    recombinant human CD109

    亚型

    IgG2a kappa
  • 应用备注

    ICC/IF_dilution: 1:100-1:200 (0.5-1.0 μg/mL)

    FACS_dilution: 0.5-1.0 μg/million cells in 0.1 ml

    IHC-frozen_dilution: 1:50-1:100 (1-2 μg/mL)

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    100 μg/mL

    缓冲液

    PBS with 0.02 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    store at 2 - 8 °C
  • 抗原

    CD109

    别名

    CD109

    背景

    CD109 is a GPI-anchored member of the alpha-2-macroglobulin (A2M) and complement family of proteins. It is expressed on activated T-cells, platelets, hematopoietic stem cells, megakaryocyte precursors, vascular endothelial cells, basal and myoepithelial cells of secretory glands, and squamous cell carcinomas. A 170-180 kDa precursor is autocatalytically reduced to 150 kDa and 120 kDa forms. On keratinocytes CD109 binds TGF-beta and associates with TGF-beta RI and TGF-beta RII, resulting in inhibition of TGF-beta signalling. Polymorphisms of CD109 include the platelet-specific Gov antigen and the blood group ABH antigens. Alloantibodies directed against these antigens result in unsuccessful platelet transfusions, neonatal alloimmune thrombocytopenia, and post-transfusion purpura. Positive control: Human platelets, blood vessels.

    途径

    Activated T Cell Proliferation
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