LY75/DEC-205 抗体 (AA 1006-1130)
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北京 101111
Quick Overview for LY75/DEC-205 抗体 (AA 1006-1130) (ABIN7863090)
抗原
See all LY75/DEC-205 (LY75) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1006-1130
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原理
- CD205 / LY75 / DEC-205 Antibody
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特异性
- DEC-205 (LY75, lymphocyte antigen 75, GP200-MR6) is a 1,695 residue (mature form) multi-lectin receptor that belongs to the MMR (macrophage mannose receptor) family of multidomain molecules. MMR family molecules mediate membrane receptor targeting to endosomes or lysosomes rich in major histocompatibility complex class II (MHC II) products. Expressed in mature dendritic cells (DC), DEC-205 contains an extracellular N-terminal cysteine-rich domain, a fibronectin type II domain, ten C-type carbohydrate recognition domains, a single transmembrane region and a small cytoplasmic C-terminal domain (31 amino acids) containing a tyrosine at 1679. DEC-205 elicits either an agonistic or antagonistic effect on IL-4 function, which is demonstrated by the ability of DEC-205 to imitate IL-4-induced maturation of epithelium or to inhibit IL-4-induced proliferation of T cells, respectively. Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.
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纯化方法
- 200ug/ml of recombinant MAb purified by Protein A/G.
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免疫原
- Recombinant fragment (around aa1006-1130) of human LY75 protein (exact sequence is proprietary)
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亚型
- IgG2b, kappa
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anti-Lymphocyte Antigen 75 (LY75) antibody
LY75 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4B10E11 unconjugated
anti-Lymphocyte Antigen 75 (LY75) antibody (PE)LY75 适用: 人 FACS 宿主: 小鼠 Monoclonal HD30 PE
anti-Lymphocyte Antigen 75 (LY75) (AA 440-680) antibodyLY75 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Antigen 75 (LY75) (AA 1520-1666) antibodyLY75 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3A4A10 unconjugated
anti-Lymphocyte Antigen 75 (LY75) antibodyLY75 适用: 人 WB, FACS, IHC (fro) 宿主: 小鼠 Monoclonal HD30 unconjugated
anti-Lymphocyte Antigen 75 (LY75) (AA 646-675) antibodyLY75 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23558 unconjugated
anti-Lymphocyte Antigen 75 (LY75) (C-Term) antibodyLY75 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Antigen 75 (LY75) (Internal Region) antibodyLY75 适用: 人, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lymphocyte Antigen 75 (LY75) antibody (PE)LY75 适用: Cow, 绵羊 FACS 宿主: 小鼠 Monoclonal IL-A114 PE
anti-Lymphocyte Antigen 75 (LY75) antibody (APC)LY75 适用: 人 FACS 宿主: 小鼠 Monoclonal HD30 APC
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))
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别名
- CD205
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背景
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C-type lectin domain family 13 member B, CD205 antigen, CLEC13B, DEC205, gp200 MR6, LY75, Lymphocyte antigen 75, Renal Cell Carcinoma (gp200)
Human tonsil, Thymus or Lymph Node.
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分子量
- 198kDa
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基因ID
- 4065, 100526664, 153563
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UniProt
- O60449
抗原
-
