Recombinant Thymidine Phosphorylase 抗体
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Quick Overview for Recombinant Thymidine Phosphorylase 抗体 (ABIN7862719)
抗原
See all Thymidine Phosphorylase (TYMP) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant Thymidine Phosphorylase / PD-ECGF (Angiogenesis Marker) Antibody
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特异性
- Recognizes a protein (amino acid 482) of 55 kDa (in vivo 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5'-deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant full-length human Thymidine Phosphorylase (TP / PD-ECGF) protein
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亚型
- IgG1, kappa
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anti-Thymidine Phosphorylase (TYMP) (AA 311-482) antibody
TYMP 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1H7 unconjugated
anti-Thymidine Phosphorylase (TYMP) (AA 29-305) antibodyTYMP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thymidine Phosphorylase (TYMP) (AA 1-200) antibodyTYMP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Thymidine Phosphorylase (TYMP) (AA 1-482) antibodyTYMP 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Thymidine Phosphorylase (TYMP) antibodyTYMP 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 小鼠 Monoclonal P-GF-44C unconjugated
anti-Thymidine Phosphorylase (TYMP) antibodyTYMP 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Monoclonal TYMP-2890R unconjugated Recombinant Antibody
anti-Thymidine Phosphorylase (TYMP) (N-Term) antibodyTYMP 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Thymidine Phosphorylase (TYMP) antibodyTYMP 适用: 人 WB, IHC (p), ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Thymidine Phosphorylase (TYMP) (AA 13-254) antibodyTYMP 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Thymidine Phosphorylase (TYMP) (N-Term) antibodyTYMP 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- Thymidine Phosphorylase (TYMP)
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别名
- Thymidine Phosphorylase
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背景
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ECGF, ECGF1, Gliostatin, hPD-ECGF, MEDPS1, MNGIE, MTDPS1, PD-ECGF, PDECGF, Platelet-derived endothelial cell growth factor, TdRPase, Thymidine phosphorylase, TP, Tymp
Bladder, Breast, Lung or Kaposi tumors (IHC)., Spleen, Liver.
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分子量
- 55kDa
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基因ID
- 1890, 180903
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UniProt
- P19971
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途径
- Signaling Events mediated by VEGFR1 and VEGFR2
抗原
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