Recombinant Smoothelin 抗体
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Quick Overview for Recombinant Smoothelin 抗体 (ABIN7862097)
抗原
See all Smoothelin (SMTN) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant Smoothelin (Differentiated Smooth Muscle Marker) Antibody
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特异性
- Smoothelin is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. In the vascular system, smoothelin expression is limited to large veins and arteries capable of pulsatile contraction. As a marker for the highly differentiated contractile smooth muscle cell, smoothelin expression is useful for studying vascular malformation and injury. It is a constituent of the smooth muscle cell cytoskeleton protein exclusively found in differentiated smooth muscle cells (SMC). Cells with SMC-like characteristics, such as myofibroblasts and myoepithelial cells, as well as skeletal and cardiac muscle do not contain smoothelin.To distinguish bladder muscularis mucosae (MM) from muscularis propria (MP) muscle bundles is crucial for accurate staging of bladder carcinoma. Strong smoothelin expression is nearly exclusively observed in muscularis propria. Therefore, the staining pattern of MP (strongly positive) and MM (negative or weakly positive) makes this antibody an attractive diagnostic tool. Anti-smoothelin immunostaining can be helpful in differentiating benign (+) from malignant smooth muscle tumors (-), and other mimics (-).
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant full-length human Smoothelin (SMTN) protein
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亚型
- IgG, kappa
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anti-Smoothelin (SMTN) antibody
SMTN 适用: 人, Cat, 小鸡, 犬, 猴, Pig WB, IHC, IHC (fro), IHC (p) 宿主: 小鼠 Monoclonal R4A unconjugated
anti-Smoothelin (SMTN) antibodySMTN 适用: 人, Cat, 小鸡, 犬, 猴, Pig WB, IHC, ICC, IHC (fro), IHC (p) 宿主: 小鼠 Monoclonal R4A unconjugated
anti-Smoothelin (SMTN) antibodySMTN 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Smoothelin (SMTN) (AA 742-906) antibodySMTN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Smoothelin (SMTN) (AA 65-325) antibodySMTN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Smoothelin (SMTN) (AA 748-911) antibodySMTN 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- Smoothelin (SMTN)
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别名
- Smoothelin
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背景
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FLJ35168, FLJ35365, FLJ35620, FLJ38597, Smoothelin, SMSMO, Smtn, SMTN_HUMAN
Human smooth muscle.
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分子量
- 59/110kDa (short/long isoforms|respectively)
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基因ID
- 6525, 149098
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UniProt
- P53814
抗原
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