PRDM1 抗体
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北京 101111
Quick Overview for PRDM1 抗体 (ABIN7864854)
抗原
See all PRDM1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- PRDM1 / BLIMP-1 Antibody
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特异性
- The development and differentiation of plasma cells, which are terminally differentiated B-cells, are induced by Blimp-1 (B lymphocyte-induced maturation protein, also designated PRDI-BF1). Blimp-1 is a transcriptional repressor that localizes to the nucleus and is considered a master regulator of terminal B-cell development. Alone, Blimp-1 is sufficient to trigger terminal B-cell differentiation. Blimp-1 upregulates the expression of syndecan-1 and J chain, represses IFN-b gene transcription and associates with HDAC to recruit it to DNA, thereby repressing c-Myc. Blimp-1 is expressed during the late stages of B-cell differentiation in immunoglobulin-secreting plasma cells, as well as in long-lived, bone marrow plasma cells. The expression of Blimp-1 defines a checkpoint beyond which fully activated B cells proceed to the plasma cell stage, whereas immature and partially activated cells are eliminated.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant full-length human PRDM1 protein
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亚型
- IgG2a
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anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 1-109) antibody
PRDM1 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2B10 unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (Internal Region) antibodyVerified PRDM1 适用: 人 WB, ELISA, IHC, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 690-825) antibodyPRDM1 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 2F1B6 unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 1-109) antibodyPRDM1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F8 unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 422-493) antibodyPRDM1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1G9 unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 690-825) antibodyPRDM1 适用: 人 ELISA, ICC 宿主: 小鼠 Monoclonal 7C11H1 unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (C-Term) antibodyVerified PRDM1 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (Middle Region) antibodyPRDM1 适用: 人, 小鼠, 大鼠, 犬, Pig, Cow, 马, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 199-409) antibodyPRDM1 适用: 人, 小鼠, Pig WB, ELISA, IHC, IP, FACS, ICC, IF 宿主: 小鼠 Monoclonal 3H2-E8 unconjugated
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) (AA 29-149) antibodyPRDM1 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))
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别名
- PRDM1
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背景
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B Lymphocyte Induced Maturation Protein 1 , Beta-interferon gene positive regulatory domain I-binding factor , BLIMP1 , Positive Regulatory Domain I Binding Factor 1 , PR domain containing 1 with ZNF domain isoform 2 , PR domain zinc finger protein 1 , PR domain-containing protein 1 , PRDI-BF1 , PRDI-binding factor 1
HeLa or MCF-7 cells.
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分子量
- 114.8kDa
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基因ID
- 639, 436023
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途径
- Regulation of Muscle Cell Differentiation
抗原
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