NMI 抗体
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北京 101111
Quick Overview for NMI 抗体 (ABIN7863575)
抗原
See all NMI 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- N myc (and STAT) Interactor / NMI Antibody
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特异性
- Nmi (for N-Myc interactor) is an interferon inducible protein that associates with multiple transcription factors, including c-Myc, n-Myc, Max, and c-Fos, which contain bHLH-ZIP, bHLH, or Zip domains. Nmi is ubiquitously expressed at low levels throughout various fetal and adult tissues and at higher levels in myeloid leukemias and cell lines overexpressing c-Myc. In addition to binding Myc proteins, Nmi also associates with the Stat family of transcription factors, where it enhances Stat-dependent transcription. Although Nmi lacks an intrinsic DNA binding or activation domain, Nmi enhances the transcriptional activity of the Stat proteins, in response to cytokine stimulation, by recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. In vitro studies indicate that Nmi, expressed in conjunction with CBP, enhances the transcriptional responsiveness of Stat5 to IL-2 stimulation five-fold over CBP alone by increasing the affinity of Stat proteins for CBP/p300.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant full-length human NMI protein
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亚型
- IgG2b
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anti-N-Myc (And STAT) Interactor (NMI) (AA 1-100) antibody
NMI 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 9D8 unconjugated
anti-N-Myc (And STAT) Interactor (NMI) (AA 1-307) antibodyNMI 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-N-Myc (And STAT) Interactor (NMI) (AA 1-100) antibodyNMI 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 9E8 unconjugated
anti-N-Myc (And STAT) Interactor (NMI) (AA 62-202) antibodyNMI 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-N-Myc (And STAT) Interactor (NMI) antibodyKD Validated NMI 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2560 unconjugated Recombinant Antibody
anti-N-Myc (And STAT) Interactor (NMI) (AA 1-307) antibodyNMI 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-N-Myc (And STAT) Interactor (NMI) (C-Term) antibodyNMI 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-N-Myc (And STAT) Interactor (NMI) (C-Term) antibodyNMI 适用: 人 WB, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-N-Myc (And STAT) Interactor (NMI) antibodyNMI 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-N-Myc (And STAT) Interactor (NMI) (AA 2-307) antibodyNMI 适用: 人 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- NMI (N-Myc (And STAT) Interactor (NMI))
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别名
- N myc Interactor
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背景
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N myc (and STAT) interactor, N myc interactor, NMI, NMYC and STAT interactor, NMYC interactor
HeLa or K562 cells.
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分子量
- 38kDa
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基因ID
- 9111, 54483
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UniProt
- Q13287
抗原
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