MPZ 抗体
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北京 101111
Quick Overview for MPZ 抗体 (ABIN7863902)
抗原
See all MPZ 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Myelin Protein Zero / MPZ Antibody
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特异性
- Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50 % of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant full-length human MPZ protein
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亚型
- IgG2a, kappa
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anti-Myelin Protein Zero (MPZ) (AA 175-248) antibody
MPZ 适用: 大鼠, 小鼠, 犬 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Myelin Protein Zero (MPZ) (C-Term) antibodyMPZ 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myelin Protein Zero (MPZ) (AA 186-215), (C-Term) antibodyMPZ 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB21459 unconjugated
anti-Myelin Protein Zero (MPZ) (AA 193-223), (C-Term) antibodyMPZ 适用: 人 WB, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-Myelin Protein Zero (MPZ) (AA 1-258) antibodyMPZ 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Myelin Protein Zero (MPZ) antibodyMPZ 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Myelin Protein Zero (MPZ) (AA 30-248) antibodyMPZ 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myelin Protein Zero (MPZ) (Internal Region) antibodyVerified MPZ 适用: 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Myelin Protein Zero (MPZ) (AA 1-258) antibodyMPZ 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3B12 unconjugated
anti-Myelin Protein Zero (MPZ) (AA 30-156) antibodyMPZ 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- MPZ (Myelin Protein Zero (MPZ))
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别名
- Myelin Protein Zero
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背景
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Charcot Marie Tooth neuropathy 1B, CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, MPZ, Myelin peripheral protein, Myelin protein P0, Myelin protein zero, MYP0_HUMAN, P0
Peripheral nerve cells.
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分子量
- 28kDa
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基因ID
- 4359, 591486
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UniProt
- P25189
抗原
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