KDM5C 抗体
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北京 101111
Quick Overview for KDM5C 抗体 (ABIN7861649)
抗原
See all KDM5C 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- KDM5C Antibody
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特异性
- SmcX, also known as JARID1C (jumonji, AT rich interactive domain 1C), MRXJ, KDM5C or XE169, is a nuclear protein that contains one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers and belongs to the JARID1 histone demethylase family. Expressed ubiquitously with highest expression in brain and skeletal muscle, SmcX functions as a histone demethylase that removes methyl groups from lysine residues on Histone H3, thereby playing a role in the histone code, as well as transcriptional regulation and chromatin remodeling. SmcX binds iron and a-ketoglutarate as cofactors and can recruit histone deacetylases to neuron silencer elements, thus repressing the transcription of neuronal genes. Defects in the gene encoding SmcX are associated with X-linked mental retardation (XLMR), a condition characterized by cognitive impairment and a low IQ. Multiple isoforms of SmcX are expressed due to alternative splicing events.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant full-length human KDM5C protein
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亚型
- IgG2c
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anti-Lysine (K)-Specific Demethylase 5C (KDM5C) antibody
KDM5C 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5C (KDM5C) (AA 275-325) antibodyKDM5C 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5C (KDM5C) (AA 45-324) antibodyKDM5C 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5C (KDM5C) (AA 10-261) antibodyKDM5C 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5C (KDM5C) (C-Term) antibodyKDM5C 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5C (KDM5C) (C-Term) antibodyKDM5C 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5C (KDM5C) antibodyKDM5C 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))
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别名
- KDM5C
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背景
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DXS1272E, JARID1C, MRX13, SMCX, XE169
HeLa cells.
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分子量
- 176kDa
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基因ID
- 8242, 631768
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UniProt
- P41229
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途径
- Warburg Effect
抗原
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