ITGAV/ITGB6 抗体
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北京 101111
Quick Overview for ITGAV/ITGB6 抗体 (ABIN7863748)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Integrin alpha V + beta 6 Antibody
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特异性
- Integrins are heterodimers composed of noncovalently associated transmembrane °™ and æ subunits. The 16 °™ and 8 æ subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors, both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Mouse fibroblasts retrovirally infected with cDNA to human beta6, Cells expressed a mouse/human avb6 chimera.
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亚型
- IgG2a, kappa
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anti-Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6) antibody
ITGAV/ITGB6 适用: 人, 小鼠, 大鼠 FACS, WB, IF (cc), IF (p), ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- ITGAV/ITGB6 (Integrin alpha V, Integrin beta 6 (ITGAV/ITGB6))
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别名
- Integrin alpha V + beta 6
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背景
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antigen identified by monoclonal antibody L230, CD 51, CD51, Integrin alpha five, integrin alpha V beta 3, Integrin alpha-V light chain, integrin alphaVbeta3, integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51), ITGAV, MSK 8, Msk8, Vitronectin receptor subunit alpha, VNRA, VTNR, ITGB6, Integrin, beta 6
Squamous cell carcinoma cells. A375M melanoma cell line. A549 cell line.
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分子量
- 150-160kDa under non-reducing conditions. Under reducing conditions|cleaved into 2 bands of ~125-130kDa +20-25kDa
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基因ID
- 3685, 3694, 436873
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UniProt
- P06756, P18564
抗原
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