Fetuin 抗体
The 小鼠 单克隆 anti-Fetuin antibody is suitable to detect Fetuin in samples from 人. It has been validated for IHC.
产品编号 ABIN7861308
发货至:
中国
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Contact Info
Our Local Distributor
中国
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北京 101111
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Quick Overview for Fetuin 抗体 (ABIN7861308)
抗原
Fetuin
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This Fetuin antibody is un-conjugated
应用范围
Immunohistochemistry (IHC)
克隆位点
AHSG-3748
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原理
- Fetuin / AHSG (alpha 2-HS glycoprotein) Antibody
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特异性
- Fetuin (also designated °™2-z-globulin or °™2-HS-glycoprotein) is a secreted plasma protein that is expressed in hepatocytes, monocyte/macrophages and in bone and is downregulated during injury and inflammation. Fetuin preferentially binds to and carries calcium and barium ions in the blood, where it is thought to mediate serum calcium homeostasis and mineralization, and to potentially participate in the transport of bioactive molecules. Additionally, fetuin has been shown to function as an acute phase anti-inflammatory mediator that is critical to regulating the innate immune response following tissue injury. During inflammation, circulating fetuin levels substantially decrease as fetuin becomes associated with the membranes of macrophages. This membrane associated form of fetuin acts as an opsonic participant by potentiating the entry of cationic small molecules into the activated macro-phage, which in turn facilitates macrophage-deactivating mechanisms. Biologically active fetuin is derived from a precursor protein that is cleaved at the aminoterminus to generate two chains held together by a single disulfide bond.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment of human AHSG protein (exact sequence is proprietary)
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亚型
- IgG1, kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- Fetuin
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背景
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59 kDa bone sialic acid-containing protein, Aa2-066, AHS, A-2-HS-glycoprotein chain B, Alpha-2-Z-globulin, HSGA Asialofetuin, Ba-alpha-2-glycoprotein, BSP, Countertrypin, Fetua, Fetuin A, Glycoprotein PP63
Human liver, kidney, testisor placenta
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分子量
- 59kDa
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基因ID
- 197, 324746
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UniProt
- P02765
抗原
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