Recombinant CKM 抗体
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北京 101111
Quick Overview for Recombinant CKM 抗体 (ABIN7865221)
抗原
See all CKM 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant Creatine Kinase MM (Biomarker for Muscular Injury &, Cardiac Damage) Antibody
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特异性
- Creatine kinases (CKs) are a large family of isoenzymes that regulate levels of ATP in subcellular compartments, where they provide ATP at sites of fluctuating energy demand by the transfer of phosphates between creatine and adenine nucleotides. Creatine kinases provide the energy of phosphate hydrolysis necessary to drive the normal function of many cellular systems including muscle, electrocytes, retina photoreceptor cells, brain cells, kidney, salt glands, myometrium, placenta, pancreas, thymus, thyroid, intestinal epithelial cells, endothelial cells, cartilage and bone cells, macrophages, blood platelets, and tumor and cancer cells. Human cytoplasmic creatine kinase-B, also designated CK-B and BCK, is a 381 amino acid, brain tissue-specific isoform of creatine kinase. Human cytoplasmic creatine kinase-M (CK-M, MCK) is a muscle tissue specific isoform of creatine kinase. Human cytoplasmic creatine kinase-Mi (Mi-CK, MtCK) is a 416 amino acid mitochondrial-specific isoform of creatine kinase. Cytosolic creatine kinases are important in the energetic regulation of Ca2+-pumps and in the maintenance of Ca2+-homeostasis. The antibody binds specifically to the human creatine-kinase-MM subtype (and not the MB or BB subtype). This antibody binds to human muscle creatine-kinase-MM, an enzyme that catalyzes the conversion of creatine and ATP to phosphocreatine and ADP, generating an ATP-buffer in the muscle. The antibody blocks CK-MM activity by 80 % .
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant human CKM protein
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亚型
- IgG, kappa
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anti-Creatine Kinase, Muscle (CKM) (AA 11-367) antibody
CKM 适用: 犬 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Creatine Kinase, Muscle (CKM) (AA 11-367) antibodyCKM 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Creatine Kinase, Muscle (CKM) (AA 11-367) antibodyCKM 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Creatine Kinase, Muscle (CKM) (AA 282-381) antibodyCKM 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1E3 unconjugated
anti-Creatine Kinase, Muscle (CKM) (N-Term) antibodyCKM 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Creatine Kinase, Muscle (CKM) (AA 1-381) antibodyCKM 适用: 人 WB, ELISA, IP, IF 宿主: 小鼠 Monoclonal 2F3-B11 unconjugated
anti-Creatine Kinase, Muscle (CKM) (AA 1-381) antibodyCKM 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal 1D10F2 unconjugated
anti-Creatine Kinase, Muscle (CKM) (N-Term) antibodyCKM 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Creatine Kinase, Muscle (CKM) (AA 11-367) antibodyCKM 适用: Pig WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Creatine Kinase, Muscle (CKM) (N-Term) antibodyCKM 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- CKM (Creatine Kinase, Muscle (CKM))
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别名
- Creatine Kinase MM
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背景
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CKM, CKMM, Creatine kinase M, Creatine kinase M chain, Creatine kinase M type, Creatine kinase M-type, Creatine kinase muscle, Creatine kinase, muscle type, M-CK, MCK, Muscle creatine kinase
Human heart tissue. Skeletal muscle lysate.
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分子量
- 43kDa
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基因ID
- 1158, 334347
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UniProt
- P06732
抗原
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