CCAR2 抗体
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北京 101111
Quick Overview for CCAR2 抗体 (ABIN7864161)
抗原
See all CCAR2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- KIAA1967 / DBC1 / CCAR2 Antibody
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特异性
- DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein, is one of the genes located within the region of chromosome 8p21.3 that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNF±, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNF±-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ER±, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant full-length human CCAR2 / KIAA1967 protein
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亚型
- IgG2a
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anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) antibody
CCAR2 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1A9G12 unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 65-917) antibodyCCAR2 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 1-923) antibodyCCAR2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 1-923) antibodyCCAR2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 654-923) antibodyCCAR2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 5-365) antibodyCCAR2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4E6 unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (Internal Region) antibodyCCAR2 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) antibodyCCAR2 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB70 unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) antibodyCCAR2 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 842-855) antibodyVerified CCAR2 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))
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别名
- KIAA1967
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背景
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CCAR2, Cell division cycle and apoptosis regulator protein 2, DBC.1, DBC1, DBIRD complex subunit KIAA1967, Deleted in breast cancer gene 1 protein, K1967_HUMAN, KIAA1967, NET35, p30 DBC, p30DBC
Expressed ubiquitously in normal tissues. Expressed in 84 to 100 % of neoplastic breast, lung, and colon tissues.
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分子量
- 102.9kDa
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基因ID
- 57805, 433722
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UniProt
- Q8N163
抗原
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