Recombinant CD19 抗体
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北京 101111
Quick Overview for Recombinant CD19 抗体 (ABIN7861019)
抗原
See all CD19 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant CD19 (B-Lymphocyte Marker) Antibody
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特异性
- CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains. CD19 is present in both benign and malignant B-cells and is considered to be the most reliable surface marker of this lineage over a wide range of maturational stages. In normal lymphoid tissue, CD19 is observed in germinal centers, in mantle zone cells, and in scattered cells of the inter-follicular areas. Anti-CD19 exhibits an overall immunoreactivity pattern similar to those of the antibodies against CD20 and CD22. However, in contrast to CD20, expression of CD19 is continuous throughout B-cell development and through terminal differentiation of B-cells into plasma cells. Anti-CD19 positivity is seen in the vast majority of B-cell neoplasms commonly at a lower intensity than normal B-cell counterparts. Plasma cell neoplasms are nearly always negative, as are T-cell neoplasms. CD19 antibody binds to the human CD19 protein, a transmembrane protein expressed in all B lineage cells including human plasma cells. CD19 plays two major roles in human B cells: it acts as an adaptor protein to recruit cytoplasmic signaling proteins to the membrane and works within the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. CD19 is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for leukemia immunotherapies.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant human CD19 protein
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亚型
- IgG, kappa
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anti-CD19 Molecule (CD19) (AA 151-250) antibody
CD19 适用: 人, 小鼠, 大鼠 FACS, WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD19 Molecule (CD19) (AA 20-291) antibodyCD19 适用: 人 FACS, WB, IHC, IF, ELISA 宿主: 小鼠 Monoclonal 8G11B7 unconjugated
anti-CD19 Molecule (CD19) (C-Term) antibodyCD19 适用: 人, 小鼠, 大鼠, 猴, 绵羊, Pig, Cow, 豚鼠, 兔, 犬, Avian, Cat, 小鸡, 驴, 山羊, Hamster, 马 WB, IHC (fro), IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-CD19 Molecule (CD19) (AA 485-556) antibodyCD19 适用: 人, 小鼠, 大鼠, 绵羊 FACS, ELISA, IHC (fro), IHC (p), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-CD19 Molecule (CD19) (pTyr531) antibodyCD19 适用: 人, 小鼠 FACS, ELISA, IHC (fro), IHC (p), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-CD19 Molecule (CD19) (AA 96-281) antibodyCD19 适用: 人 FACS, IHC, ELISA 宿主: 小鼠 Monoclonal CD19-3116 unconjugated
anti-CD19 Molecule (CD19) antibodyCD19 适用: 人 FACS, WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD19 Molecule (CD19) (AA 143-172) antibodyCD19 适用: 人 FACS, WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CD19 Molecule (CD19) (AA 160-258) antibodyCD19 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD19 Molecule (CD19) (AA 1-556) antibodyCD19 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- CD19 (CD19 Molecule (CD19))
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别名
- CD19
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背景
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B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, CVID3, Leu-12, T-cell surface antigen Leu-12
Human tonsil, lymph node or spleen.
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分子量
- 95kDa
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基因ID
- 930, 652262
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UniProt
- P15391
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途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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