SIGLEC10 抗体 (AA 500-697)
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Quick Overview for SIGLEC10 抗体 (AA 500-697) (ABIN7860287)
抗原
See all SIGLEC10 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 500-697
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原理
- SIGLEC10 Antibody
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特异性
- Siglec-10 (sialic acid-binding Ig-like lectin 10) is a 697 amino acid protein belonging to the immunoglobulin superfamily. The N-terminal Ig-like domain of Siglec-10 contains a sialic acid-binding site and the C-terminal cytoplasmic region of Siglec-10 contains two immunoreceptor tyrosine-based inhibitor motifs (ITIMs), which are involved in the modulation of cellular responses through SH2 domains. With most expression in spleen, bone marrow and peripheral blood lymphocytes, such as monocytes, natural killer cells and eosinophils, it is likely that Siglec-10 functions as an inhibitory receptor in the immune response. Importantly, Siglec-10 mRNA is found to be highly upregulated in eosinophils at sites of inflammation in asthmatics, suggesting that Siglec-10 may be an appropriate target for new approaches of immunomodulatory therapy. There are six named isoforms of Siglec-10 that are a result of alternative splicing. All isoforms exists as single-pass transmembrane proteins, except for isoform 6, which is secreted.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa500-697) of human SIGLEC10 protein (exact sequence is proprietary)
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亚型
- IgG2, kappa
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anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (AA 571-697) antibody
SIGLEC10 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C5 unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (AA 572-697) antibodySIGLEC10 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (AA 571-697) antibodySIGLEC10 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (AA 589-696) antibodySIGLEC10 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (AA 589-696) antibodySIGLEC10 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D11 unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (Extracellular Domain) antibody (PE)SIGLEC10 适用: 人 FACS 宿主: 小鼠 Monoclonal 5G6 PE
anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (AA 321-420) antibodySIGLEC10 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) (Extracellular Domain) antibodySIGLEC10 适用: 人 IHC, ELISA, IP 宿主: 小鼠 Monoclonal 5G6 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))
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别名
- SIGLEC10
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背景
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mSiglec G, PRO940, sialic acid binding Ig like lectin 10 Ig like lectin 7, Sialic acid binding Immunoglobulin like lectin 10, Siglec G, siglec like gene 2, Siglec like protein 2, Siglecg, SLG2
Expressed by peripheral blood leukocytes (eosinophils|lung|monocytes and a natural killer cell subpopulation). Isoform 5 is found in lymph node|ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow|spleen a
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分子量
- 77kDa
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基因ID
- 89790, 284813
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UniProt
- Q96LC7
抗原
-
