CHGB 抗体 (AA 250-450)
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北京 101111
Quick Overview for CHGB 抗体 (AA 250-450) (ABIN7859640)
抗原
See all CHGB 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 250-450
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原理
- Chromogranin B / CHGB (Neuroendocrine Marker) Antibody
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特异性
- Chromogranins (secretogranins) are acidic glycoproteins that localize within secretory granules of endocrine, neuroendocrine and neuronal tissue. Family members include chromogranin A (Chr-A), chromogranin B (Chr-B, also known as secretogranin I) chromogranin C (also known as secretogranin II or Sg II), secretogranin III (Sg III or SCG3). High levels of Chr-A expression is a characteristic of neuroendocrine tumors. Pancreastatin is a peptide derived from Chr-A which inhibits Insulin secretion, exocrine pancreatic secretion and gastric acid secretion. Pancreastatin exists as two forms, the major form is expressed in stomach and colon extracts. In neuroendocrine cells the level Sg II has been shown to increase four-fold in response to histamine, while levels of Chr-A and Chr-B showed little or no increase. Sg III is an acidic secretory protein expressed in neuronal and endocrine cells. In the anterior lobe of the rat pituitary gland, Sg III is present in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, though not in somatotropes. Sg III and carboxypeptidase E (CPE) bind specifically to cholesterol-rich secretory granule (SG) membranes.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa250-450) of human CHGB protein (exact sequence is proprietary)
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亚型
- IgG1, kappa
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anti-Chromogranin B (Secretogranin 1) (CHGB) (AA 496-669) antibody
CHGB 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chromogranin B (Secretogranin 1) (CHGB) (AA 407-677) antibodyKO Validated CHGB 适用: 小鼠, 大鼠 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chromogranin B (Secretogranin 1) (CHGB) antibodyCHGB 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Chromogranin B (Secretogranin 1) (CHGB) antibodyCHGB 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB5075 unconjugated Recombinant Antibody
anti-Chromogranin B (Secretogranin 1) (CHGB) (AA 309-484) antibodyCHGB 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chromogranin B (Secretogranin 1) (CHGB) (AA 1-677) antibodyCHGB 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Chromogranin B (Secretogranin 1) (CHGB) (AA 328-677) antibodyCHGB 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chromogranin B (Secretogranin 1) (CHGB) (AA 1-300) antibodyCHGB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Chromogranin B (Secretogranin 1) (CHGB) (AA 315-482) antibodyCHGB 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chromogranin B (Secretogranin 1) (CHGB) (AA 448-664) antibodyCHGB 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- CHGB (Chromogranin B (Secretogranin 1) (CHGB))
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别名
- Chromogranin B
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背景
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CCB peptide, Cg B, CgB, Chgb, SCG1, SCG1_HUMAN, Secretogranin 1, Secretogranin B, Secretogranin I, SgI
Human adrenal gland, kidney, pancreas, cerebellum or stomach.
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分子量
- 76/110kDa
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基因ID
- 1114, 516874
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UniProt
- P05060
抗原
-
