Fodrin (AA 2351-2475) 抗体
This 小鼠 单克隆 antibody specifically detects Fodrin in IHC. It exhibits reactivity toward 人.
产品编号 ABIN7863431
发货至:
中国
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Quick Overview for Fodrin (AA 2351-2475) 抗体 (ABIN7863431)
抗原
Fodrin
适用
人
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Immunohistochemistry (IHC)
克隆位点
SPTAN1-3507
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抗原表位
- AA 2351-2475
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原理
- Fodrin / Alpha Spectrin II (SPTAN1) / NEAS Antibody
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特异性
- Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous °™ and æ chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin °™ I and spectrin æ I are present in erythrocytes, whereas spectrin °™ II (also designated fodrin °™) and spectrin æ II (also designated fodrin æ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin °™ II, a neuronal cytoskeleton protein.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment of human SPTAN1 protein (around aa2351-2475) (exact sequence is proprietary))
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亚型
- IgG
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anti-Fodrin antibody
适用: 人 IHC, WB 宿主: 小鼠 Monoclonal AA6 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- Fodrin
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背景
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Alpha-II spectrin, brain, EIEE5, Fodrin alpha chain, NEAS, Non erythrocytic spectrin alpha, non-erythroid alpha chain, SPECA, Spectrin alpha chain brain, Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), Spna2, SPTA2
Human colon or kidney tissues (IHC).
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分子量
- 240kDa
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基因ID
- 6709, 372331
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UniProt
- Q13813
抗原
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