Haptoglobin 抗体 (AA 100-250)
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北京 101111
Quick Overview for Haptoglobin 抗体 (AA 100-250) (ABIN7858955)
抗原
See all Haptoglobin (HP) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 100-250
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原理
- Haptoglobin (HP) Antibody
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特异性
- Haptoglobin (Hp) is a blood plasma protein that functions to bind free Hemoglobin that has been released from erythrocytes, thereby inhibiting its oxidative activity. During this process, Haptoglobin sequesters the iron within Hemoglobin, preventing iron-utilizing bacteria from benefitting from hemolysis. This function suggests that Haptoglobin concentrations may increase in response to inflammation. The resulting Haptoglobin-Hemoglobin complex is then removed by the reticulo-endothelial system. Due to cleavage of a common precursor protein during protein synthesis, Haptoglobin consists of two a and two b chains, connected by disulfide bridges. In human, Haptoglobin exists in two allelic forms designated Haptoglobin 1 (Hp1) and Haptoglobin 2 (Hp2), where Hp2 is the result of a partial Hp1 gene duplication. There are three known phenotypes of human Haptoglobin: Hp1-1, Hp2-1 and Hp2-2, which may be associated with diabetes and cardiovascular disease pathology and a susceptibility to Parkinson s and Crohn s disease. Haptoglobin levels are useful in diagnosing hemolytic anemia, the abnormal breakdown of red blood cells. Haptoglobin is expressed in mammalian hepatocytes as well as other tissues such as skin, lung and kidney.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa100-250) of human HP protein (exact sequence is proprietary)
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亚型
- IgG1, kappa
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anti-Haptoglobin (HP) (AA 118-281) antibody
HP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Haptoglobin (HP) (AA 104-346) antibodyHP 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Haptoglobin (HP) (AA 123-307) antibodyHP 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Haptoglobin (HP) (AA 44-157) antibodyHP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Haptoglobin (HP) (AA 296-322), (Center) antibodyHP 适用: 人 WB, FACS, IHC (p), IF 宿主: 兔 Polyclonal RB28443 unconjugated
anti-Haptoglobin (HP) (AA 299-326), (Middle Region) antibodyHP 适用: 人 WB, FACS, IHC (p), IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Haptoglobin (HP) (AA 168-319) antibodyHP 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C12 unconjugated
anti-Haptoglobin (HP) (AA 295-322), (Center) antibodyHP 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21463 unconjugated
anti-Haptoglobin (HP) (AA 251-350) antibodyHP 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Haptoglobin (HP) (AA 70-332) antibodyHP 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- Haptoglobin (HP)
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别名
- Haptoglobin
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背景
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Binding peptide (BP), Haptoglobin alpha chain / alpha(1S) beta, Haptoglobin alpha(2FS) beta, Haptoglobin beta chain, Haptoglobin, alpha polypeptide, Haptoglobin, beta polypeptide, HP, HP2 ALPHA2, HPA1S, HPT, MGC111141, Zonulin
Human liver.
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分子量
- 15-18 kDa ( chain), 45kDa ( chain)
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基因ID
- 3240, 513711, 702099
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途径
- Transition Metal Ion Homeostasis
抗原
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