ERG 抗体 (AA 1-300)
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北京 101111
Quick Overview for ERG 抗体 (AA 1-300) (ABIN7858824)
抗原
See all ERG 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-300
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原理
- ERG / ETS Transcription Factor (Prostate Cancer Marker) Antibody
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特异性
- ERG (ETS-related gene) is a proto-oncogene, a member of the ETS family of transcription factors. The ERG gene encodes for a nuclear protein, also called ERG, which is involved in hematopoietic and endothelial development. ERG remains constitually expressed in endothelial cells in blood and lymphatic vessels, and in bone marrow stem cells. ERG is expressed in virtually all endothelial neoplasms including hemangioendothelioma, angiosarcoma and Kaposi sarcoma. ERG is overexpressed secondary to gene rearrangement in cases of prostate adenocarcinoma, gastrointestinal stromal tumor, synovial sarcoma, meningioma, epithelioid sarcoma, malignant rhabdoid tumor, acute myeloid leukemia and blastic extramedullary myeloid tumor, and rarely Ewing sarcoma / primitive peripheral neuroectodermal tumor, chondrosarcoma, osteosarcoma, and rhabdomyosarcoma. For the identification of endothelial differentiation ERG seems more sensitive and specific than any other marker. Moreover, the interpretation is often easier due to the nuclear reaction, which also allows for double stains with cytoplasmic markers like podoplanin. Among carcinomas, ERG is highly specific for prostate, while the sensitivity is moderate.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa1-300) of human ERG (exact sequence is proprietary)
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亚型
- IgG1, kappa
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anti-ERG, ETS transcription factor (ERG) antibody
ERG 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 4H7 unconjugated
anti-ERG, ETS transcription factor (ERG) (C-Term) antibodyVerified ERG 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-ERG, ETS transcription factor (ERG) (C-Term) antibodyERG 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-ERG, ETS transcription factor (ERG) antibodyERG 适用: 人, 犬 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3E12 unconjugated
anti-ERG, ETS transcription factor (ERG) antibodyERG 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 5F12 unconjugated
anti-ERG, ETS transcription factor (ERG) (C-Term) antibodyERG 适用: 人, 小鼠 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-ERG, ETS transcription factor (ERG) antibodyERG 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-ERG, ETS transcription factor (ERG) (AA 1-160) antibodyERG 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-ERG, ETS transcription factor (ERG) antibodyERG 适用: 人, 小鼠 WB, IF 宿主: 小鼠 Monoclonal 5D10 unconjugated
anti-ERG, ETS transcription factor (ERG) (AA 1-486) antibodyERG 适用: 人 IHC, ELISA, IF, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- ERG (ERG, ETS transcription factor (ERG))
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别名
- ERG
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背景
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ERG, ERG/EWS fusion gene, ERG/FUS fusion gene, ERG/TMPSSR2 fusion gene, ERG1, ETS-related, KCNH2, Oncogene ERG, p55, TMPRSS2/ERG fusion
Human tonsil, Ewing sarcoma or prostate adenocarcinoma.
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分子量
- 55kDa
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基因ID
- 2078, 473819
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UniProt
- P11308
抗原
-
