PVRL4 抗体 (AA 1-200)
Our Local Distributor
北京 101111
Quick Overview for PVRL4 抗体 (AA 1-200) (ABIN7858662)
抗原
See all PVRL4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 1-200
-
原理
- Nectin 4 / Nectin Cell Adhesion Molecule 4 / PVRL4 Antibody
-
特异性
- Homologous to the poliovirus receptor (PVR/CD155), the nectin immunoglobulin superfamily comprises four known isoforms (-1, -2, -3, and -4). The ectodomain of nectin family members comprises three Ig-like domains (V, C, C). Nectins localize at the adherens junctions (AJ) in epithelial and endothelial cells where they serve as adhesion molecules. Actin-based AJs play a role in mechanical adhesion, cellular morphogenesis and cellular differentiation. Nectin associates with the actin cytoskeleton through its interaction with the actin filament-binding protein afadin. Nectin 4 and afadin co-localize at cadherin-based adherens junctions in MDCKII epithelial cells. Nectin 4 and nectin 3 share a common binding region in the V domain of Nectin 1 and thus compete for Nectin 1 binding. The Nectin 3/4 binding domain maps to the C-C'-C''-D æ strands of the V domain of Nectin 1. Unlike other nectins, which are more widely expressed, Nectin 4 is mainly expressed in the placenta.
-
纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
-
免疫原
- Recombinant fragment (around aa1-200) of human NECTIN4 protein (exact sequence is proprietary)
-
亚型
- IgG2a, kappa
-
-
anti-Poliovirus Receptor-Related 4 (PVRL4) antibody
PVRL4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 91-199) antibodyPVRL4 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 151-250) antibodyPVRL4 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (Internal Region) antibodyPVRL4 适用: 人, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 84-96), (Extracellular) antibodyPVRL4 适用: 小鼠 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 31-139) antibodyPVRL4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D7 unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 1-510) antibodyPVRL4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 371-510) antibodyPVRL4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) antibodyPVRL4 适用: 人 FACS 宿主: Human, 兔 Chimeric DMC438 unconjugated Fc fragment Recombinant Antibody
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 239-266) antibodyPVRL4 适用: 人 WB 宿主: 兔 Polyclonal RB37608 unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
浓度
- 1.0 mg/mL
-
缓冲液
- Prepared in 10 mM PBS
-
储存液
- Azide free
-
储存条件
- -20 °C,-80 °C
-
储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
-
有效期
- 24 months
-
-
- PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))
-
别名
- Nectin 4
-
背景
-
Ig superfamily receptor LNIR family, Nectin 4, poliovirus receptor-related 4, Processed poliovirus receptor-related protein 4, PRR4, PVRL4
Human tonsil, placenta or breast.
-
分子量
- 66kDa
-
基因ID
- 81607, 492490
-
UniProt
- Q96NY8
-
途径
- Cell-Cell Junction Organization
抗原
-
