Neurogenin 3 抗体 (AA 1-200)
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Quick Overview for Neurogenin 3 抗体 (AA 1-200) (ABIN7864474)
抗原
See all Neurogenin 3 (NEUROG3) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-200
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原理
- NEUROG3 / Neurogenin 3 / NGN3 (Transcription Factor) Antibody
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特异性
- This antigen is a transcription factor that interacts with NKX2-2 to regulation transcription of NEUROD1. The neurogenin family of proteins belongs to the basic helix-loop-helix (bHLH) superfamily and consists of Neurogenin 1, Neurogenin 2 and Neurogenin 3 (also designated ngn3). bHLH members are transcriptional regulators that determine cell fate. Neurogenin 3 is expressed in discrete regions of developing neurons and in the embryonic pancreatic islets of Langerhans. HNF-6 (hepatocyte nuclear factor 6) acts as a positive regulator of Neurogenin 3 by binding to and stimulating the neurogenin gene promoter. Neurogenin 3 is involved in the initial differentiation of the four islets cell types, while a network of transcription factors, including Hlxb9, Isl1, NeuroD, Nkx-2.2, Nkx-6.4, Pax-4, Pax-6, PDX-1 and Mash1, are required for final differentiation. Neurogenin 3 acts upstream of NeuroD in a bHLH cascade. Neurogenin 3 activates the expression of NeuroD at the onset of islet cell differentiation through box sequences E1 and E3 in the NeuroD promoter.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa1-200) of human NEUROG3 protein (exact sequence is proprietary)
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亚型
- IgG2b, kappa
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anti-Neurogenin 3 (NEUROG3) (AA 40-69), (N-Term) antibody
NEUROG3 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB02913 unconjugated
anti-Neurogenin 3 (NEUROG3) (AA 1-101) antibodyNEUROG3 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 4E9 unconjugated
anti-Neurogenin 3 (NEUROG3) (AA 1-101) antibodyNEUROG3 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 4B7 unconjugated
anti-Neurogenin 3 (NEUROG3) (AA 1-83) antibodyNEUROG3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neurogenin 3 (NEUROG3) (AA 61-160) antibodyNEUROG3 适用: 人, 小鼠, 大鼠, Pig WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neurogenin 3 (NEUROG3) antibodyNEUROG3 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neurogenin 3 (NEUROG3) (N-Term) antibodyNEUROG3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Neurogenin 3 (NEUROG3) antibodyNEUROG3 适用: 人 WB, IHC, IF 宿主: 小鼠 Monoclonal 3B5 unconjugated
anti-Neurogenin 3 (NEUROG3) (AA 1-214) antibodyNEUROG3 适用: 人 WB 宿主: 小鼠 Monoclonal 1800CT113-128-46 unconjugated
anti-Neurogenin 3 (NEUROG3) (AA 93-214) antibodyNEUROG3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- Neurogenin 3 (NEUROG3)
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别名
- NEUROG3
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背景
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ATH4B, Atoh5, bHLHa7, Class A basic helix-loop-helix protein 7, Math4B, NEUROG3, Neurogenin-3, Neurogenin3, NGN-3, ngn3, Protein atonal homolog 5
colon|HeLa cells. Human fetal gut|liver or heart.
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分子量
- 23.54kDa
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基因ID
- 50674, 288655
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UniProt
- Q9Y4Z2
抗原
-
