IL-31 抗体 (AA 1-164)
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北京 101111
Quick Overview for IL-31 抗体 (AA 1-164) (ABIN7864470)
抗原
See all IL-31 (IL31) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-164
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原理
- Interleukin-31 / IL-33 Antibody
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特异性
- IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa1-164) of human IL31 protein (exact sequence is proprietary)
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亚型
- IgG2b, kappa
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anti-Interleukin 31 (IL31) antibody
IL31 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 31 (IL31) (AA 13-40), (N-Term) antibodyIL31 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB22575 unconjugated
anti-Interleukin 31 (IL31) (AA 24-164) antibodyIL31 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 31 (IL31) (AA 31-130) antibodyIL31 适用: 人 ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 31 (IL31) (AA 21-120) antibodyIL31 适用: 小鼠 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 31 (IL31) (AA 28-154) antibodyIL31 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 31 (IL31) (AA 19-49), (N-Term) antibodyIL31 适用: 人, 小鼠 WB, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 31 (IL31) antibodyIL31 适用: 人, 小鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 31 (IL31) (AA 55-183) antibodyIL31 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal A3 unconjugated
anti-Interleukin 31 (IL31) (AA 24-164) antibodyIL31 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5G9 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- IL-31 (IL31) (Interleukin 31 (IL31))
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别名
- Interleukin-31
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背景
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IL-31, Interleukin 31
bone marrow|colon|Detected at low levels in testis|kidney|skeletal muscle|small intestine and trachea.|thymus
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分子量
- 18 kDa
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基因ID
- 386653, 569071
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UniProt
- Q6EBC2
抗原
-
