CCL23 抗体 (AA 1-120)
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北京 101111
Quick Overview for CCL23 抗体 (AA 1-120) (ABIN7864500)
抗原
See all CCL23 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-120
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原理
- CCL23 / Myeloid Progenitor Inhibitory Factor 1 Antibody
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特异性
- Small inducible cytokine A23 precursor (CCL23), or CK-b-8, is a chemokine that binds to the receptor CCR1. It is involved in the immune response and inhibits production of polymorphonuclear leukocytes (PMNs) and monocytes in bone marrow. In addition, CCL23 has a splice variant, CK-b-8-1, and both variants chemoattract lymphocytes, monoctyes and neutrophils. CCL23 also promotes angiogenesis and endothelial cell migration via its actions on the CCR1 receptor. Proinflammatory proteases cleave an N-terminal domain of CCL23, improving the potency of its CCR1-mediated signaling up to 1000- fold in vitro. N-truncated CCL23 is found in high levels in synovial fluids of rheumatoid arthritis patients, suggesting a role of protease release during an inflammatory response. High levels of CCL23 mRNA expression occur in human fetal bone osteoblasts and chondrocytes, indicating a possible role for CCL23 in the recruitment of osteoclast precursors to the sites of bone reabsorption.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa1-120) of human CCL23 protein (exact sequence is proprietary)
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亚型
- IgG2, kappa
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anti-Chemokine (C-C Motif) Ligand 23 (CCL23) antibody
CCL23 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Ligand 23 (CCL23) (AA 1-137) antibodyCCL23 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Ligand 23 (CCL23) antibodyCCL23 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Ligand 23 (CCL23) (AA 1-137) antibodyCCL23 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Ligand 23 (CCL23) (C-Term) antibodyCCL23 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Ligand 23 (CCL23) (AA 22-120) antibodyCCL23 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- CCL23 (Chemokine (C-C Motif) Ligand 23 (CCL23))
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别名
- CCL23
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背景
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C C motif chemokine ligand 23, C6 beta chemokine, CK-beta-8, CKB 8, Ckb-8-1, CKB8, Hmrp-2a, Macrophage inflammatory protein 3, MIP3, MPIF1, Myeloid progenitor inhibitory factor 1, OTTHUMP00000163948, SCYA 23, SCYA23, Small inducible cytokine subfamily A (Cys-Cys), member 23, Small inducible cytokine subfamily A, member 23
High levels in adult lung|liver|skeletal muscle and pancreas.
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分子量
- 13kDa
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基因ID
- 6368, 169191
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UniProt
- P55773
抗原
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